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| Name | Class |
|---|---|
| University of Pennsylvania | OTHER |
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The goal of the research project is to investigate the influence of training status on ingestive behavior and postprandial physiological responses in the human body. The investigators aim to understand how regular training influences the choice and amount of food consumed, as well as the associated physiological processes, including changes in the spectrum of gut hormones. The investigators are particularly interested in how these factors differ between individuals who train regularly compared to those who do not follow a structured training program.
The research project aims to translate findings from previous animal experiments to humans and to examine whether and how training affects food handling and physiological responses, similar to observations made in rodents. This information could significantly contribute to improving recommendations for diet and physical activity in the population.
The goal of the proposed research is to identify the differences in ingestive behavior that might be caused by the training status in humans after long-term structured exercise. For this, the investigators plan to investigate and cross-sectionally compare microstructural parameters of ingestive behavior between individuals with trained and untrained status when offered three different meals (high-carbohydrate, high-fat, high-sucrose lactose-free milk) separately or concurrently.
Furthermore, the investigators propose to explore a possible correlation between microstructural parameters of ingestive behavior and postprandial levels of several gut hormones, and to investigate the differences in the composition and activity of the gut microbiome between the two groups, especially in relation to the observed ingestive behavior. Finally, the investigators will investigate the relationship between ingestive behavior and body composition separately for the two groups.
The microstructure of ingestive behavior of both male and female individuals in relation to training status has never been investigated in a direct measurement approach before and the investigators of this project are the only one that currently have both the technical requirements as well as the necessary experience to carry out such studies.
The previous research project "Direct measurement of changes in food selection and intake behavior after RYGB surgery" (NCT04933305, NCT03747445) was successful. Although recruitment and retention of study participants was significantly hindered by the COVID-19 pandemic after March 2020, the investigators were able to publish four peer-reviewed scientific articles out of the proposed studies so far. Four additional manuscripts are currently in preparation.
The present research project builds logically on previous work in the field of bariatric surgery and builds a new collaborations with Prof. J. Nicholas Betley and Dr. Lavinia Boccia (University of Pennsylvania, USA). This collaboration will surely lead to relevant findings which will be published in at least two peer-reviewed publications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants with trained Status | Trained status: continuous participation in a structured training program for at least the past six months, in addition to meeting the minimum requirement of physical activity of 150 min of moderate physical activity or 75 min of vigorous physical activity per week. | ||
| Participants with untrained Status | Untrained status: No participation in any structured training program for the last six months, in addition to not performing physical activity above 150 min of moderate physical activity or 75 min of vigorous physical activity per week. |
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| Measure | Description | Time Frame |
|---|---|---|
| Energy Intake from Liquid Meal Consumption | Total energy intake (in kilocalories) from consumption of high-carbohydrate, high-sucrose, and high-fat lactose-free milk during each visit. Intake is measured using a drinkometer device that quantifies the exact volume consumed, which is then converted into kilocalories based on the known energy density of each meal type. The unit of measure is kilocalories (kcal). | From enrolment to the end of the study participation through four study visits within three months. |
| Macrostructure of Ingestive Behavior (Rate of Energy Intake) | The rate of energy intake is calculated for each participant during the ingestion of each of the three test stimuli, based on standardized measurements from the drinkometer system. This measure reflects the average caloric intake per second over the course of the test stimulus consumption. Energy intake is determined by the volume of liquid consumed, multiplied by the known caloric density of the test stimulus, and divided by the duration of the ingestion period. The unit of measure is kilocalories per second (kcal/s). This outcome is assessed during the first three study visits, in which a single test stimulus is administered at each visit. It is not measured during the fourth study visit, where all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months |
| Macrostructure of Ingestive Behavior (Meal Duration) | Meal duration is defined as the total time taken by each participant to consume each of the three test stimuli, measured using the standardized drinkometer system. For each stimulus, the duration is recorded from the initiation of ingestion (first measurable suck) to the completion of consumption (last measurable suck). The unit of measure is seconds (s). This outcome is assessed during the first three study visits, each involving the administration of a single test stimulus. Meal duration is not measured during the fourth study visit, where all three test stimuli are offered to participants simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma GLP-1 Concentration | Change in GLP-1 concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
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Inclusion Criteria:
Exclusion Criteria:
History of previous metabolic and bariatric surgery,
Current use of medications for medical treatment (excluding contraceptive measures),
Current use of over-the-counter medications for weight loss or appetite control,
Current medical diagnosis of metabolic disorders (such as type
1 or 2 diabetes mellitus),
Use of antibiotics in the last two months,
History of use of probiotics (excluding yogurt and sauerkraut),
Smoking,
Biological or surgical menopause,
Polycystic ovary syndrome (PCOS),
Pregnancy, lactation, or current attempt of conception, and
History of chronic substance abuse.
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Participants in the trained group are recruited from a rowing club affiliated with the University of Zürich (UZH) and Federal Technical institute of Zürich (ETH).
Participants in the untrained group are recruited from students and employees of UZH and ETH.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich | Zurich | Canton of Zurich | 8091 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31125091 | Background | Zouhal H, Sellami M, Saeidi A, Slimani M, Abbassi-Daloii A, Khodamoradi A, El Hage R, Hackney AC, Ben Abderrahman A. Effect of physical exercise and training on gastrointestinal hormones in populations with different weight statuses. Nutr Rev. 2019 Jul 1;77(7):455-477. doi: 10.1093/nutrit/nuz005. | |
| 34203776 | Background |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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Blood samples are collected from venous blood before, directly after, and 30 minutes after the meal test. Plasma samples will be isolated from blood samples and stored at -80° C for later analysis. The analysis of DNA is not planned in this study. Nevertheless, plasma can contain cell-free DNA (cfDNA). Considering that no solution for the stabilisation of nucleic acid is added to the plasma samples, a complete or meaningful sequencing of the cfDNA can hardly be expected from the plasma samples collected in this study.
Stool samples are collected at two different time points to establish the circadian rhythm of the gut microbiome. Metagenomics and metatranscriptomics analysis will be performed only on microbial genetic material.
| Macrostructure of Ingestive Behavior (Number of Sucks) | The primary outcome is the number of sucks performed by each participant during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "suck" is defined as a discrete negative pressure event generated by the participant to draw in liquid, as detected by the drinkometer's calibrated weight sensors. For each stimulus, the total number of sucks is recorded as a simple count, with the unit of measure being "number (n)." The outcome is assessed during the first three study visits, each of which features a single test stimulus administered in a standardized fashion. This outcome is not measured during the fourth study visit, in which all three test stimuli are offered simultaneously to the participant. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Suck Energy Intake) | Suck energy intake is defined as the total amount of energy (in kilocalories) consumed by the participant during each individual suck, measured for each of the three test stimuli using a standardized drinkometer system. For each test stimulus, the total caloric intake is calculated by multiplying the volume of liquid ingested by its caloric density and summing the values across all measured sucks. The unit of measure is kilocalories (kcal). This outcome is assessed during the first three study visits, where each visit involves a single test stimulus. Suck energy intake is not measured during the fourth study visit, in which all three test stimuli are presented to the participant simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Suck Duration) | Suck duration is defined as the time span of each individual suck performed by the participant during the ingestion of each of the three test stimuli, as measured by a standardized drinkometer system. For each test stimulus, the duration of every suck is recorded from the initiation to the completion of the negative pressure event. The unit of measure is seconds (s). This outcome is assessed during the first three study visits, where a single test stimulus is administered at each visit. Suck duration is not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Suck Rate) | Suck rate is defined as the average energy intake of liquid ingested per second during each individual suck, measured for each of the three test stimuli using a standardized drinkometer system. For each test stimulus, the energy intake consumed during each suck is divided by the corresponding suck duration to determine the rate of ingestion for that event. The unit of measure is kilocalories per second (kcal/s). This outcome is assessed during the first three study visits, where a single test stimulus is administered at each visit. Suck rate is not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Suck Maximal Rate) | Suck maximal rate is defined as the highest instantaneous rate of liquid ingestion (in kilocalories per second) achieved during any single suck by the participant for each of the three test stimuli, as measured using a standardized drinkometer system. For each test stimulus, the maximal rate is determined by identifying the suck with the greatest energy intake per unit time among all measured sucks during the ingestion period. The unit of measure is kilocalories per second (kcal/s). This outcome is assessed during the first three study visits, with each visit involving a single test stimulus. Suck maximal rate is not measured during the fourth study visit, where all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Burst Number) | Burst number is defined as the total count of distinct bursts performed by the participant during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "burst" is operationally defined as a sequence of successive sucks separated by brief pauses, typically reflecting a rhythmic drinking pattern. For each test stimulus, the number of such bursts is recorded as an integer value. The unit of measure is "number of bursts" (n). This outcome is assessed during the first three study visits, where a single test stimulus is administered at each visit. Burst number is not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Burst Duration) | Burst duration is defined as the total elapsed time of each individual burst performed by the participant during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "burst" is operationally defined as a sequence of consecutive sucks separated by brief pauses. For each burst, the duration is measured from the onset of the first suck to the end of the last suck within the burst. The unit of measure is seconds (s). This outcome is assessed during the first three study visits, with each visit involving a single test stimulus. Burst duration is not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Burst Energy Intake) | Burst energy intake is defined as the total amount of energy intake (in kilocalories) consumed during each individual burst by the participant, measured for each of the three test stimuli using a standardized drinkometer system. A "burst" is operationally defined as a sequence of consecutive sucks separated by brief pauses. For each burst, the energy intake is calculated by multiplying the volume of liquid ingested within the burst by the energy density of the test stimulus. The unit of measure is kilocalories (kcal). This outcome is assessed during the first three study visits, each involving a single test stimulus. Burst size is not measured during the fourth study visit, in which all three test stimuli are offered simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Burst Rate) | Burst rate is defined as the average rate of energy intake during each individual burst performed by the participant for each of the three test stimuli, as measured using a standardized drinkometer system. For each burst, the total energy intake (in kilocalories) is divided by the duration of the burst (in seconds) to determine the average rate of energy intake for that burst. The unit of measure is kilocalories per second (kcal/s). This outcome is assessed during the first three study visits, each involving a single test stimulus. Burst rate is not measured during the fourth study visit, in which all three test stimuli are offered simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Number of Sucks per Burst) | Number of sucks per burst is defined as the average count of individual sucks occurring within each burst during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "burst" is operationally defined as a sequence of consecutive sucks separated by brief pauses. For each burst, the total number of sucks is recorded, and the outcome is typically reported as the mean number of sucks per burst. The unit of measure is "number of sucks per burst" (n). This outcome is assessed during the first three study visits, where a single test stimulus is administered at each visit. Number of sucks per burst is not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Inter-Burst Intervals) | Inter-burst interval is defined as the elapsed time between the end of one burst and the onset of the subsequent burst during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "burst" is operationally defined as a sequence of consecutive sucks separated by brief pauses. The inter-burst interval quantifies the temporal spacing between bursts and is recorded in seconds (s). This outcome is assessed during the first three study visits, each involving a single test stimulus. Inter-burst intervals are not measured during the fourth study visit, in which all three test stimuli are offered simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Microstructure of Ingestive Behavior (Inter-Sucks Intervals) | Inter-suck interval is defined as the elapsed time between the end of one suck and the initiation of the subsequent suck during the ingestion of each of the three test stimuli, as measured using a standardized drinkometer system. A "suck" is operationally defined as a discrete negative pressure event corresponding to the drawing in of liquid. The inter-suck interval quantifies the temporal spacing between individual sucks within a burst or throughout the test stimulus consumption, and is recorded in seconds (s). This outcome is assessed during the first three study visits, each involving a single test stimulus. Inter-suck intervals are not measured during the fourth study visit, in which all three test stimuli are presented simultaneously. | From enrolment to the end of the study participation through three of four study visits within three months. |
| Plasma GIP Concentration | Change in GIP concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Amylin Concentration | Change in amylin concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma PYY Concentration | Change in PYY concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Ghrelin Concentration | Change in ghrelin concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Leptin Concentration | Change in leptin concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Insulin Concentration | Change in insulin concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma CCK Concentration | Change in CCK concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Glucagon Concentration | Change in glucagon concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Plasma Serotonin Concentration | Change in serotonin concentration (pmol/L) from pre-drink to post-drink (immediately and 30 minutes after ingestion), across the three meal types. Unit of measure is picomoles per liter (pmol/L). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Subjective Appetite Sensation: Hunger | Self-reported hunger rated on a 100-mm visual analogue scale (VAS). Unit of Measure: millimeters (mm). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Subjective Appetite Sensation: Fullness | Self-reported fullness rated on a 100-mm visual analogue scale (VAS). Unit of Measure: millimeters (mm). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Subjective Appetite Sensation: Desire To Eat | Self-reported desire to eat rated on a 100-mm visual analogue scale (VAS). Unit of Measure: millimeters (mm). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Subjective Appetite Sensation: Nausea | Self-reported nausea rated on a 100-mm visual analogue scale (VAS). Unit of Measure: millimeters (mm). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Subjective Appetite Sensation: Abdominal Discomfort | Self-reported abdominal discomfort rated on a 100-mm visual analogue scale (VAS). Unit of Measure: millimeters (mm). | Measured at 3 time points per visit: before the drinkometer test, directly at the end of the drinkometer test, and 30 minutes after the end of the drinkometer test. |
| Gut Microbiome Composition (Alpha and Beta Diversity) | Microbiome diversity is measured via 16S rRNA sequencing of stool samples collected at two distinct circadian time points: one sample in the morning and one in the late afternoon. The unit of measure is the Shannon index for alpha diversity and the UniFrac distance for beta diversity. While participants are instructed to collect samples at these specific times to capture circadian variation, the exact time of collection is dependent on each participant's individual bowel movement patterns and may vary accordingly. | Up to 14 days after study enrollment (microbiome diversity measured from two stool samples per participant: one in the morning, after afternoon; timing based on participant's natural bowel movement occurrence) |
| Gut Microbiome Functional Activity (Metabolite Analysis) | Quantification of microbial metabolites in stool samples. The unit of measure is micromoles per gram stool (µmol/g). | Up to 14 days after study enrollment (microbiome diversity measured from two stool samples per participant: one in the morning, after afternoon; timing based on participant's natural bowel movement occurrence) |
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