In decades, the outcome of patients with peripherial T-cell lymphomas is dismal, especially in relapsed or refractory population. After failure to the frontline treatment, patients have limited treatment options and elderly population usually have no chance to undergo transplantation due to age or comorbidity, etc. Golidocitinib and chidamide were approved in treating r/r PTCL in China, while azacytidine has been demonstrated its anti-tumor activity in PTCL as well.

This study aims to explore the efficacy and safety of golidocitinib combined with azacytidine and chidamide in the patients with peripheral T-cell lymphoma who are eligible for intensive chemotherapy or transplantation.

Inclusion Criteria:

1. Histopathologically confirmed peripheral T-cell lymphoma;
2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2;
3. Expected survival of ≥12 weeks;
4. Measurable disease lesions;
5. Any conditions considered ineligible for intenvive chemotherapy, including but not limted to age > 60 years, at least one comorbidity scored 3 points, or more than 4 comorbidities scored 2 points each according to the CIRS scale;
6. Female participants of childbearing potential and male participants with partners of childbearing potential must agree to and adhere to effective contraceptive measures during the treatment period and for 180 days after the last dose of the study drug;
7. Participants must voluntarily join the study, sign the informed consent form, demonstrate good compliance, and cooperate with follow-up assessments.

Exclusion Criteria:

1. Involvement of the central nervous system (CNS);

2. History of malignancies except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix;

3. Uncontrolled cardio- and cerebro-vascular disease, blood clotting disorders, connective tissue diseases, serious infectious diseases and other diseases

4. Left ventricular ejection fraction<50%

5. Laboratory measures meet the following criteria at screening (unless caused by lymphoma):

   • Neutrophils<1.5×10^9/L
   • Platelets<75×10^9/L (Platelets<50×10^9/L in case of bone marrow involvement)
   • ALT or AST is 2 times higher than the upper limits of normal (ULN), AKP and bilirubin are 1.5 times higher than the ULN.
   • Creatinine is 1.5 times higher than the ULN.

6. HIV-infected patients

7. Patients with psychiatric disorders or patients who are known or suspected to be unable to fully comply with the study protocol

8. Pregnant or lactation

9. Require treatment with strong/moderate CYP3A inhibitors or inducers.

10. Inability to swallow capsules or presence of diseases that significantly affect gastrointestinal function, such as malabsorption syndrome, post-bariatric surgery, inflammatory bowel disease and complete or incomplete intestinal obstruction

11. Other medical conditions determined by the researchers that may affect the study