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This study aimed to determine the role of early urine alkalinization and N-acetylcysteine administration for the prevention of renal damage following hair dye intoxication
Paraphenylenediamine (PPD) is an organic compound with the formula C6H4(NH2). It is the derivative of aniline, which is a white substance that turns black on oxidation, called paraphenylaniline, which is soluble in hydrogen peroxide.
Intoxication with hair dye (PPD) has become a standard method of intentional self-harm in some parts of Africa and Asia because it is cheap and readily available in the market(5).
It can cause contact dermatitis in susceptible individuals. The glutathione (GSH) levels are depleted in PPD poisoning. The antioxidant GSH plays a vital role in the maintenance of cell viability, DNA replication, and the regulation of immune cell functions. N-acetylcysteine (NAC) acts as an antioxidant both directly as a glutathione substitute and indirectly as a precursor for glutathione.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Experimental | Patients received early N-Acetylcysteine. |
|
| Control group | Active Comparator | Patients received late N-Acetylcysteine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early N-Acetylcysteine | Drug | Patients received N-acetyl cysteine early (at admission) in the course of treatment of acute hair dye poisoning. |
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| Measure | Description | Time Frame |
|---|---|---|
| Mean difference of the serum creatinine | Mean difference of the serum creatinine was recorded. | Immediately after N-Acetylcysteine Administration (Up to 1 hour) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Valley university | Qina | 83523 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| Late N-Acetylcysteine | Drug | Patients received the standard treatment of N-acetyl cysteine after starting organ affection in the course of treatment of acute hair dye poisoning. |
|