The goal of this observational study is to investigate the neuropsychological states of People Living With HIV(PLWH), the prevalence of social and psychological stress adaptation overload and poor episodic memory in PLWH. The main questions it aims to observe are: to observe the prevalence of psychopathic states in PLWH with different viral loads and to compare the effects of different treatments on the prevalence of psychopathic states in PLWH. It is helpful to understand the mental health burden faced by PLWH in China, to improve clinicians' awareness of PLWH's mental and psychological state, and formulate targeted psychological support, treatment and nursing programs.

Our research is a prospective cohort of PLWH, mainly observing the differences in the prevalence of AO among different treatment strategies; Secondly, observe: ① The changes of neuropsychological symptoms such as newly diagnosed PLWH, AO, and Poor EM compared with the baseline; ② Changes in neuropsychological symptoms such as PLWH, AO, and Poor EM after treatment with different treatment regimens compared to the baseline; ③ For PLWH at different stages, after half a year of treatment, the changes of neuropsychological symptoms such as PLWH, AO, and Poor EM compared with the baseline; ④ Changes in Interpersonal Stress, Work Stress and Daily Stress conditions of PLWH compared with the baseline.

Inclusion Criteria:

1. Diagnosis: PLWH can be diagnosed if one of the following three items is met according to the Chinese AIDS Diagnosis and Treatment Guidelines (2021):

   ① HIV antibody screening test positive and HIV supplementation test positive (antibody supplementation test positive or nucleic acid qualitative test positive or nucleic acid quantification>5000 copies/mL);

   ② Has a history of epidemiology or clinical manifestations related to AIDS, tested positive for HIV nucleic acid twice;

   ③ HIV isolation test positive;

2. Receive treatment at the hospital participating in the study; Age range: 18-80 years old, male or female not limited;

3. Patients who are willing to participate in this clinical study and sign the informed consent form for this study.

Exclusion Criteria:

Individuals who meet any of the following criteria are not eligible to participate in this study:

1. Pregnant or lactating women; Men and women who are preparing for natural conception or artificial assisted reproduction;
2. Severe aphasia, physical disability, or any other non neuropsychological factors that may hinder the completion of the assessment;
3. is currently involved in other research;
4. Having a tendency towards violence may endanger the safety of others.

People Living With HIV