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| Name | Class |
|---|---|
| Rawalpindi Medical College, Pakistan | OTHER |
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As baby grows inside the womb of mother, heart and other organs develop. The heart activity can be recorded by placing a transducer on the belly of mother. The tracing obtain provides information about heart rate, any increase or decrease in heart rate and how much it varies with time. Variation in heart rate along with increase is indicator of fetal well being. Some mothers are at high risk of pre-term birth that is baby delivery before 37 weeks of gestation. In such cases steroids are given to mother to accelerate lung development of the baby so that it can easily adapt to outside world. Dexamethasone and Betamethasone are commonly used steroids which can also effect fetal heart activity.
Some patients are at high risk of Pre term birth and therefore they are advised antenatal steroids which facilitates fetal lung development preparing it for smoother transition for extra-uterine life. Dexamethasone and Betamethasone are commonly used for this purpose but differently effect fetal cardiac activity as evident by CTG changes and awareness of these phenomena would prevent iatrogenic delivery of preterm fetuses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Betamethasone | Experimental | Intramuscular injection of Betamethasone 12mg will be administered on 2 consecutive days |
|
| Group Dexmaethasone | Active Comparator | 24mg of Dexamethasone in two divided doses will be given Intramuscularly over 24 hours apart |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Betamethason Sodium Phosphate | Drug | Intramuscular injection of Betamethasone 12mg will be administered on 2 consecutive days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean number of accelerations on fetal cardiotocography | Before intervention, 2 and 4 days after intervention | |
| Long term heart rate variability on fetal cardiotocography | Before intervention, 2 and 4 days after intervention |
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Inclusion Criteria:
Exclusion Criteria:
Pregnant Females with Gestational age 30-37 weeks are included in the study
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ifra Shafique, MBBS | Contact | +92-3039007053 | ifra.shafique1944@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ifra Shafique, MBBS | Rawalpindi Medical Unviersity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Holy Family Hospital, Rawalpindi Medical University | Recruiting | Rawalpindi | Punjab Province | 46000 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10376858 | Background | Rotmensch S, Liberati M, Vishne TH, Celentano C, Ben-Rafael Z, Bellati U. The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities. A prospective randomized trial. Acta Obstet Gynecol Scand. 1999 Jul;78(6):493-500. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| C028994 | betamethasone sodium phosphate |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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Participants will be randomly divided into two groups using computer generated numbers and will be masked to the treatment they receive. The person assessing outcome i.e. fetal cardiotography activity will be masked to the treatment participant received.
| Dexamethasone | Drug | two doses of 12mg of IM Dexamethasone given 24 hours apart |
|
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |