Comparison of Skin Condition After Hyaluronic Acid Application on Dry vs. Moist Skin

Comparison of Different Methods of Hyaluronic Acid Application on Skin Parameters

This study aims to compare the effects of two different methods of applying hyaluronic acid (HA) on skin parameters in healthy individuals. HA is a widely used ingredient in skincare products due to its hydrating properties. However, it is unclear whether applying HA to dry or pre-moistened skin provides better results in terms of skin hydration and texture.

In this non-invasive, interventional trial, 23 healthy volunteers aged 18 to 50 will be randomly assigned to two groups. One group will apply HA to dry skin, while the other will apply HA to moistened skin. Skin parameters will be measured before and after the intervention to assess hydration, transepidermal water loss, and overall skin condition.

The aim is to determine the optimal method of HA application that maximizes its effectiveness in improving skin quality. Participants may benefit from improved skin hydration and increased awareness of the best application method for their skin type. No significant risks are expected from participation.

Inclusion Criteria:

• Healthy individuals aged 18 to 50 years
• Willingness to apply the product daily for 3 weeks
• Ability to attend all scheduled skin assessments (baseline + weekly)
• Provided written informed consent

Exclusion Criteria:

• Known allergy or sensitivity to hyaluronic acid or any component of the product
• Active skin diseases or dermatological conditions in the facial area
• Use of systemic or topical corticosteroids or retinoids within 4 weeks prior to study
• Pregnancy or breastfeeding
• Participation in another clinical trial within the past 30 days