A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Risk-Stratified Screening Strategy for Lung Cancer

A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Risk-Stratified Screening Strategy for Lung Cancer

A nationwide population-based multi-center RCT enrolling ≥60,000 eligible residents to compare screening effectiveness between risk-prediction-model-driven and traditional guideline-based high-risk lung cancer screening strategies.

Inclusion Criteria:

1. Residents with local household registration residing continuously in the region for ≥3 years.
2. Aged 40-74 years at enrollment.

Exclusion Criteria:

1. Prior diagnosis of lung cancer (histologically/cytologically confirmed)
2. Currently receiving active treatment for any malignancy.
3. Presence of severe comorbidities with life expectancy <5 years
4. Participation in any lung cancer screening program within 5 years.
5. Functional dependency (ADL score ≤2) OR unwillingness to comply with protocol-required follow-up.
6. Declined to provide written informed consent.