Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care

Incidence of Respiratory Depression of Remimazolam Compared With Propofol for Monitored Anesthesia Care During Hysteroscopy

The comparison of incidence of respiratory depression between remimazolam and propofol under monitored anesthesia care for hysteroscopic surgery

• Non-invasive blood pressure, electrocardiogram, and oxygen saturation sensors are attached.

  • Wear an oxygen mask (5L per minute), and place the sampling line for end-tidal carbon dioxide partial pressure measurement inside the nose.

    • Check the randomization table to determine the drug to be administered, and prepare propofol or remimazolam accordingly.

      • Record the baseline values (0 min).

        • Start administration of Remifentanil.

          ⑥ Administer anesthesia to adjust the maintenance dose to reach a sedation level of 2 or less on the MOAA/S scale.

          ⑦ Adjust the remifentanil dose according to the patient's response

          ⑧ When the target sedation level is reached, the surgical preparation process and surgery begin, and the study variables are observed and recorded at 5-minute intervals.

          ⑨ Stop drug administration upon end of surgery.

          ⑩ After confirming proper recovery of consciousness and spontaneous breathing, leave the recovery room.

          ⑪ Before leaving the recovery room, check the complete recovery and investigate the patient's satisfaction with anesthesia.

Inclusion Criteria:

• ASA PS 1-2
• Elective hysteroscopic surgery under monitored anesthesia care
• No drug abuse history

Exclusion Criteria:

• BMI > 30 kg/m2
• Hepatic or renal insufficiency
• Alcohol abuse
• Respiratory, hemodynamic compromise, or diseases
• History of general/regional anesthesia during the last month
• A patient who is taking sedatives or analgesics
• Under the investigator's judgment