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This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PDPH Group | Patients who developed postdural puncture headache (PDPH) following spinal anesthesia for cesarean section. |
| |
| Non-PDPH Group | Patients who did not develop PDPH after spinal anesthesia for cesarean section |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PDPH | Other | Observational analysis of preoperative inflammatory markers (e.g., NLR, PLR, SIRI) in relation to PDPH development following spinal anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postdural Puncture Headache (PDPH) incidence | The occurrence of PDPH symptoms within 10 days following spinal anesthesia in obstetric patients, as documented in medical records. | Within 10 days postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
Only female participants were included, as the study population consisted of obstetric patients undergoing cesarean section under spinal anesthesia.
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The study population consists of obstetric patients who underwent cesarean section under spinal anesthesia between January 2020 and December 2024 at a single tertiary center.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ilke dolgun | Contact | +905555485632 | ilkeser2004@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istinye Üniversity | Recruiting | Istanbul | Merkez Mahallesi | 34250 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30725984 | Background | Olawin AM, Das JM. Spinal Anesthesia. 2022 Jun 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK537299/ | |
| 38850761 | Result | Sahin R, Tanacan A, Serbetci H, Agaoglu Z, Haksever M, Kara O, Sahin D. The Association of Systemic Immune-Inflammation Index (SII), Systemic Immune-Response Index (SIRI), and Neutrophil-to-Lymphocyte Ratio (NLR) with Cesarean Scar Pregnancy (CSP). J Reprod Immunol. 2024 Aug;164:104275. doi: 10.1016/j.jri.2024.104275. Epub 2024 Jun 4. |
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| ID | Term |
|---|---|
| D051299 | Post-Dural Puncture Headache |
| ID | Term |
|---|---|
| D051271 | Headache Disorders, Secondary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 36808350 | Result | Bai YY, Xi Y, Yin BB, Zhang JH, Chen F, Zhu B. Reference intervals of systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio during normal pregnancy in China. Eur Rev Med Pharmacol Sci. 2023 Feb;27(3):1033-1044. doi: 10.26355/eurrev_202302_31199. |
| D009422 | Nervous System Diseases |