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To guide the administration of intravenous albumin by lung ultrasound in decompensated cirrhosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional albumin group | No Intervention | Conventional albumin group | |
| Lung ultrasound guided albumin administration group | Experimental | Lung ultrasound guided albumin administration group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lower albumin dosage | Drug | A fixed dose of 35 grams of albumin on they one and day two. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall mortality at 30 days | Overall mortality at 30 days | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory failure | Number of Participants with respiratory failure, as defined as a requirement of greater than 10/L min og supplemental oxygen, a SpO2 lower than 92% on room temperature or an arterial blood oxyen concentration (pO2) lower than 60 mmHg. | Every 24 hours, during hospitalization, (assesed up to 28 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Médico ISSEMyM | Metepec | State of Mexico | 52170 | Mexico |
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| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D058186 | Acute Kidney Injury |
| D001201 | Ascites |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
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| Acute kidney injury |
Number of Participants with acute kidney injury, as defined by the KDIGO criteria, being KDIGO 1 an increment in serum creatinine over baseline values of 0.3 mg/dL, KDIGO 2-2.9 times over baseline, KDIGO 3, 3 times over baseline. |
| Every 24 hours, during hospitalization, (assesed up to 28 days) |
| Resolution of SBP | Number of Participants with resolution of SBP: Defined as a reduction of 25% of WBC in ascites performed through check up paracentesis at day three. | Day three of antibiotic treatment initiated for spontaneous bacterial peritonitis. |
| Development of variceal hemorrhage | Number of Participants with development of variceal hemorrhage: Defined as upper GI bleeding due to gastroesophageal varices confirmed by endoscopy | During hospitailization, (assesed up to 28 days) |
| acute-on-chronic liver failure | Number of Participants with development of acute on chronic liver failure, as defined by ther Ec-CLF criteria, which asses biochemical function of six organ systems: liver, kidney, brain, coagulation, circulation, and lungs. Each organ system is graded on a scale of 1 to 3, with higher scores indicating more severe organ dysfunction. | During hospitailization, (assesed up to 28 days) |
| Total hospitalization time | Total hospitalization time | 30 days |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |