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Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using data from the Korean National Health Insurance Service (K-NHIS) database to evaluate the impact of regular physical activity.
It is well established that patients with T2DM and abdominal obesity have worse clinical outcomes. This holds true even among individuals with a normal body weight but central (abdominal) obesity. In this study, the investigators aimed to determine whether engaging in regular physical activity (defined as vigorous exercise at least three times per week) is associated with improved clinical outcomes in normal-weight individuals with abdominal obesity. Specifically, we compared the incidence of MACCE between normal-weight patients with type 2 diabetes who had abdominal obesity and those who did not.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Abdominal obesity | Individuals were classified as having abdominal obesity. |
| |
| Without abdominal obesity | Individuals were classified as not having abdominal obesity. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Regular physical activity | Behavioral | Moderate-to-vigorous physical activity at least three times per week. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiac and cerevrovascular events (MACCE) | Composite of all-cause death, myocardial infarction, ischemic stroke, heart failure | 10 years after diagnosed T2DM |
| Measure | Description | Time Frame |
|---|---|---|
| All cause death | Death from all cause | 10 years after diagnosed T2DM |
| myocardial infarction | MI with hospitalization | 10 years after diagnosed T2DM |
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Inclusion Criteria:
- Patients who were newly diagnosed with T2DM and had a normal body weight at the time of diagnosis.
Exclusion Criteria:
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Patients who were newly diagnosed with T2DM and had a normal body weight at the time of diagnosis.
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D009043 | Motor Activity |
| D056128 | Obesity, Abdominal |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| No regular physical activity | Behavioral | The group that did not engage in physical activity according to the guidelines |
|
| Ischemic stroke | Ischemic stroke after diagnosed T2DM | 10 years after diagnosed T2DM |
| Heart failure | HF with hospitalization | 10 years after diagnosed T2DM |
| D001519 | Behavior |
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |