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The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | Participants will include CBD users and non users |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress Intervention | Other | Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in subjective states (stress, anxiety, positive affect) | Participants will self-report the extent to which they have felt stressed, overwhelmed, anxious/nervous, cheerful, and happy during the last 30 minutes before acute stress, immediately after acute stress, and after a recovery period. The Subjective States Questionnaire will be used to score responses. The minimum values are 0 (not at all) and the maximum values are 7 (very strongly). Higher scores mean more stress, more anxiety, and more positive affect. | 2.5 hours |
| Change in cardiovascular activity and cortisol | Saliva will be collected (for later cortisol assays) and cardiovascular activity will be measured before, during, and after acute stress. | 2.5 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stress and Resilience Research Labs | Contact | 2187268623 | umdbml@d.umn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Mustafa al'Absi | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Recruiting | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D040701 | Stress Disorders, Traumatic, Acute |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D003419 | Crisis Intervention |
| ID | Term |
|---|---|
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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Single group assignment; all participants experience baseline rest, acute stress tasks, and recovery rest.
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