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The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections.
The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cefazolin antibiotic prophylaxis in ventricular shunt surgery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cefazolin antibiotic prophylaxis | Other | Determination of cerebrospinal fluid concentration |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cefazolin concentration in the cerebrospinal fluid | Cefazolin concentration in the cerebrospinal fluid. | The measure is made when the dura mater is opened just before the valve implantation. |
| Measure | Description | Time Frame |
|---|---|---|
| blood cefazolin concentration | Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences. | Blood samples are made before injection |
| blood cefazolin concentration |
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Inclusion Criteria:
Age >18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Baptiste BOUCHIER, MD | Contact | 03.88.12.70.81 | 0033 | baptiste.bouchier@chru-strasbourg.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpitaux Universitaires de Strasbourg | Strasbourg | 67091 | France |
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Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences. |
| Blood samples are made 30 minutes , after injection |
| blood cefazolin concentration | Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences. | Blood samples are made 1hour after injection |
| blood cefazolin concentration | Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences. | Blood samples are made 2 hours after injection |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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