Twenty-five patients with atopic dermatitis applied lidocaine cream plus a moisturizer to the right limb and lidocaine cream alone to the left limb, twice daily for four weeks.

Inclusion Criteria:

1. Male or female patients aged 18-65 years.
2. Clinical diagnosis of atopic dermatitis according to the 2020 Guidelines for the Diagnosis and Treatment of Atopic Dermatitis in China (symmetrical eczematous lesions for ≥6 months plus personal/family atopy history or elevated IgE/eosinophilia).
3. Voluntarily signed informed consent form.

Exclusion Criteria:

1. Active heart, liver, kidney, or other serious systemic illness.
2. History of viral or bacterial infection within 1 month prior to enrollment.
3. Immunocompromised patients or those receiving systemic immunosuppressive therapy.
4. Known allergy to lidocaine, moisturizer components, or any study-related topical agents.
5. Pregnant or breastfeeding women.
6. Use of topical corticosteroids or calcineurin inhibitors within 2 weeks prior to enrollment.