A Randomized Phase 2/3 Study of Navlimetostat (BMS-986504) in Combination With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
A Randomized Phase 2/3 Study of Navlimetostat (BMS-986504) in Combination With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion
Inclusion Criteria
Exclusion Criteria
Note: One cycle of SoC treatment prior to randomization will be allowed for participants who require immediate treatment if clinically indicated.
Clinical.Trials@bms.com855-907-3286
Phoenix, Arizona 85054, United States
480-342-4800
Omaha, Nebraska 68130, United States
Columbus, Ohio 43210, United States
CABA, Buenos Aires CP1280AEB, Argentina
1121571056
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ, Argentina
+541138850425
Liège, 4000, Belgium
São Caetano do Sul, São Paulo 09541-270, Brazil
São José do Rio Preto, São Paulo 15090000, Brazil
Sofia, 1431, Bulgaria
Sofia, 1527, Bulgaria
Nanchang, Jiangxi 330209, China
Hangzhou, Zhejiang 310003, China
Bogotá, Cundinamarca 111511, Colombia
Rennes, Ille-et-Vilaine 35033, France
Vandœuvre-lès-Nancy, Meurthe-et-Moselle 54511, France
Tours, 37032, France
Hksar, 0, Hong Kong
85222554095
New Delhi, National Capital Territory of Delhi 110029, India
Ramat Gan, Central District 5265601, Israel
97235307096
Haifa, Northern District 3109601, Israel
97247776700
Bologna, 40138, Italy
Verona, 37134, Italy
Otashi, Gunma 373-8550, Japan
Shiwa-gun Yahaba-cho, Iwate 028-3695, Japan
Shimotsuga, Tochigi 321-0293, Japan
Bunkyo-ku, Tokyo 1138603, Japan
Lembah Pantai, Kuala Lumpur 59100, Malaysia
60379492299
Prabuty, Pomeranian Voivodeship 82-550, Poland
Bucharest, Bucharest 022338, Romania
Florești, Cluj 407280, Romania
40742206212
Cheongju-si, Chungcheongbuk-do [Chungbuk] 28644, South Korea
Seoul, Seoul-teukbyeolsi [Seoul] 03722, South Korea
Hospitalet, Barcelona [Barcelona] 08907, Spain
34932607283
Majadahonda, Madrid, Comunidad de 28222, Spain
Izmir, Karsiyaka, İzmir 009035575, Turkey (Türkiye)
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