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Video-assisted thoracoscopic lung resection (VATS) is a minimally invasive surgical approach frequently used in the treatment of lung cancers. The most commonly used analgesic technique for this surgery is the paravertebral block with a single peroperative injection of local anesthetic. However, a recent study conducted at our institution revealed that this approach provided less relief than expected in some patients. In light of these results, it becomes crucial to distinguish between technical failures (absence of sensitive anesthesia) and the intrinsic limits of the chosen regional analgesia technique (pain originating from an unanesthetized area or pain despite the presence of sensitive anesthesia) in order to better relieve patients.
This study aims to objectively assess the areas of anesthesia obtained through three methods of paravertebral block to evaluate their respective performance and optimize post-VATS analgesic management.
Video-assisted thoracoscopic lung resection (VATS) is a minimally invasive surgical approach frequently used in the treatment of lung cancers. Compared to traditional thoracotomy, it is associated with reduced acute postoperative pain and a faster recovery. However, this pain often remains moderate to severe and can, if poorly controlled, promote the development of chronic pain. A multimodal analgesic strategy is essential to limit the use of opioids and their side effects. The most commonly used analgesic technique is the paravertebral block. As part of the optimized recovery protocols at our institution, a single peroperative injection of local anesthetic, guided by thoracoscopy, is currently favored. This technique, which is simple and safe, promotes rapid mobilization of the patient. However, a recent study conducted at our institution revealed that this approach provided less relief than expected in some patients. In light of these results, it becomes crucial to distinguish between technical failures (absence of sensitive anesthesia) and the intrinsic limits of the chosen regional analgesia technique (pain originating from an unanesthetized area or pain despite the presence of sensitive anesthesia) in order to better relieve patients.
This study aims to objectively assess the areas of anesthesia obtained through three methods of paravertebral block to evaluate their respective performance and optimize post-VATS analgesic management.
The primary objective of the study is to compare the success rate of creating sensitive anesthesia of the thoracic wall in the acute postoperative phase of video-assisted thoracoscopic lung resection according to various administration methods (transpleural approach by the surgeon vs percutaneous approach by the surgeon vs ultrasound guided approach by the anesthesiologist).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Paravertebral block using percutaneous, transpleural or ultrasound guidance technique | The investigators aim to conduct a prospective observational study including patients having a paravertebral block undergoing a VATS lung surgery. The paravertebral block administration technique will vary sequentially, meaning that the first 30 patients included will receive the percutaneous technique, and the next 30 will receive the transpleural technique by the surgeon. The other 30 patients will receive the paravertebral block under ultrasound guidance by the anesthesiologist. Paravertebral block will be administered at two levels, T4 and T7, using the percutaneous, the transpleural or ultrasound guided technique. It will be administered by the surgeon (percutaneous and transpleural) or by the anesthesiologist (ultrasound guided) directly after the installation of the thoracoscope and before the start of lung and lymph node resection. The local anesthetic will be bupivacaine 0.5% with 5 mcg/mL of adrenaline for a total volume of 0.4 mL/kg. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evaluation of the hypoesthesia of the thorax | Other | In the recovery room, a member of the research team will come to assess the presence of hypoesthesia (loss of sensation) of the thorax using ice and a Von Frey filament applied at three different sections: midscapular, midaxillary and midclavicular. |
| Measure | Description | Time Frame |
|---|---|---|
| Success rate of the sensory block | The success rate of the sensory block, defined as a hypoesthetic level to ice or the Von Frey filament of at least T3 to T8 in the recovery room, assessed at mid-scapular, mid-axillary, and mid-clavicular. | One hour after the surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Severity of acute postoperative pain | The severity of acute postoperative pain according to the visual analog scale for pain (VAS, 0 to 100 mm, where 0 means "no pain" and 100 means the "worst possible pain.") at rest and during coughing, at the thorax 1 hour after surgery. | One hour after the surgery |
| Postoperative morphine-equivalents consumption |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for elective anatomical pulmonary resection by VATS at two institutions
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alex Moore, MD | Contact | 514-890-8000 | 12132 | alex.moore@umontreal.ca |
| Julie Desroches, PhD | Contact | 514-890-8000 | 24542 | julie.desroches.chum@ssss.gouv.qc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Alex Moore, MD | Centre hospitalier de l'Université de Montréal (CHUM) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de l'Universite de Montreal | Recruiting | Montreal | Quebec | H2X 3E4 | Canada |
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The total amount of morphine equivalents received perioperatively, including pre-emergence and recovery room doses. |
| Perioperative |
| Total duration in the operating room | Total lenght of stay of the patient in the operating room | At the end of the surgery |
| Time to recovery room discharge | The time before reaching the discharge criteria for the patient to leave the recovery room | 24 hours |
| Quality of the local anesthetic diffusion | The anesthesiologist in the operating room or the surgeon will visually assess the quality of local anesthetic diffusion (approximate number of levels) following the paravertebral block, considering possible technical or anatomical constraints. | After the parabertebral block, during the surgery |
| Incidence of nausea related to opioid consumption | Evaluation of the incidence of nausea (yes or no) in the recovery room | 24 hours |
| Incidence of vomiting related to opioid consumption | Evaluation of the incidence of vomiting (yes or no) in the recovery room | 24 hours |
| Incidence of pruritus related to opioid consumption | Evaluation of the incidence of pruritus (yes or no) in the recovery room | 24 hours |
| Incidence of postoperative hypotension requiring medical intervention | Evaluation of the incidence of postoperative hypotension requiring medical intervention (yes or no) in the recovery room | 24 hours |