Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard... | NCT07061977 | Trialant

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard... | NCT07061977 | Trialant

Official Title: NRG-GY037: A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab Versus Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer
Brief Summary: This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.
Detailed Description: PRIMARY OBJECTIVE:

I. To determine whether induction immunotherapy (IO) and chemotherapy prior to concurrent chemoradiation therapy (CCRT) + IO improves progression-free survival (PFS) compared to CCRT+IO alone.

SECONDARY OBJECTIVES:

I. To assess whether induction IO and chemotherapy prior to CCRT+IO improves the overall survival (OS) compared to CCRT+IO alone.

II. To determine the nature and degree of toxicity of induction IO and chemotherapy prior to CCRT + IO as compared to concurrent CCRT+IO as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0.

III. To determine the impact on CCRT start, CCRT completion time, and number of cycles of cisplatin administered; with induction IO and chemotherapy prior to CCRT+IO arm as compared to CCRT+IO.

IV. To assess the association between allostatic load and PFS/OS. V. To assess the predictive value of the integrated biomarker: PD-L1 expression at baseline for progression free survival.

VI. To assess the prognostic and predictive value of the integrated biomarker: circulating tumor deoxyribonucleic acid (ctDNA) at baseline and at 3 months post radiation therapy (RT) for progression free survival.

VII. To explore radiotherapy quality pretreatment scores conducted by expert review with assistance from artificial intelligence (AI) models and correlation with outcomes.

EXPLORATORY OBJECTIVES:

I. To assess the evolution of T cell receptor (TCR) repertoire on treatment and its correlation with clinical outcomes.

II. To identify pre-treatment tumor microenvironment biomarkers predictive of outcomes.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM 1:

CHEMORADIATION: Patients receive cisplatin intravenously (IV) once weekly (QW) for 5 weeks and pembrolizumab IV over 30 minutes every 3 weeks (Q3W) for 5 doses. Patients also undergo radiation therapy once daily 5 days per week for 25-29 treatments in weeks 1-5 followed by brachytherapy up to twice per week for 4-5 treatments in weeks 5-7. Treatment is given in the absence of disease progression or unacceptable toxicity

MAINTENANCE: Patients receive pembrolizumab IV over 30 minutes every 6 weeks (Q6W) for 15 cycles in the absence of disease progression or unacceptable toxicity.

Patients undergo positron emission tomography (PET) scan, computed tomography (CT) scan, chest x-ray and/or magnetic resonance imaging (MRI) and blood sample collection throughout the study.

ARM 2:

INDUCTION: Patients receive carboplatin IV and paclitaxel IV QW on weeks 1-3 and pembrolizumab IV over 30 minutes Q3W on weeks 1 for each cycle. Cycles repeat every 3 weeks for 2 cycles in the absence of disease progression or unacceptable toxicity.

CHEMORADIATION: Patients receive cisplatin IV QW for 5 weeks and pembrolizumab IV over 30 minutes every Q3W for 5 doses. Patients also undergo radiation therapy once daily 5 days per week for 25-29 treatments in weeks 7-11 followed by brachytherapy up to twice per week for 4-5 treatments in weeks 11-13. Treatment is given in the absence of disease progression or unacceptable toxicity

MAINTENANCE: Patients receive pembrolizumab IV over 30 minutes Q6W for 14 cycles in the absence of disease progression or unacceptable toxicity.

Patients undergo PET scan, CT scan, chest x-ray and/or MRI and blood sample collection throughout the study.

After completion of study treatment, patients are followed up every 3 months for 2 years then every 6 months for 3 years.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Patients must have pathologically confirmed newly diagnosed cervical cancer. Eligible pathologic types: squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma

Patients must have locally advanced cervical cancer (LACC) with T3 or T4 disease with or without lymph node involvement:

IIIA (T3aN0M0)

IIIB (T3bN0M0)

IIIC1(T3aN1M0, T3bN1M0)

IIIC2 (T3aN2M0, T3bN2M0)

IVA (T4aN0M0, T4aN1M0, T4aN2M0) No prior hysterectomy defined as removal of the entire uterus.

NOTE: prior partial/subtotal hysterectomy for reasons other than cervical cancer are eligible to participate in the study. No plan to perform a hysterectomy as part of initial cervical cancer therapy.

No paraaortic lymph node (PALN) metastases above the T12/L1 interspace.

Note: Nodal status can be confirmed by imaging (CT, MRI, or PET/CT), fine needle aspirate/core biopsy, extra peritoneal biopsy, laparoscopic biopsy, or lymphadenectomy.

Radiologic definition of lymph node staging:

N1:

One or more pelvic lymph nodes with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or

One or more pelvic lymph nodes with short axis diameter of ≥ 10 mm and standardized uptake value maximum (SUVmax) ≥ 2.5 by fludeoxyglucose (FDG)-PET

N2:

One or more para-aortic lymph node with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or

One or more para-aortic lymph node with short axis diameter of ≥ 10 mm and SUVmax ≥ 2.5 by FDG-PET

No prior definitive surgical, radiation, or systemic therapy for cervical cancer

No prior immunotherapy

No prior pelvic radiation therapy for any disease

Age ≥ 18

Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2

Not pregnant and not nursing

Absolute neutrophil count (ANC) ≥ 1,500 cells/mm^3

Platelets ≥ 100,000 cells/mm^3

Hemoglobin ≥ 8 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobulin [Hgb] ≥ 8 g/dl is acceptable)

Creatinine clearance (CrCL) of ≥ 50 mL/min by the Cockcroft-Gault formula

Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled)

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN

Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better

No active infection requiring parenteral antibiotics

No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacille Calmette Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines are live attenuated vaccines and are not allowed

No diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior registration

No active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed

No history of (non-infectious) pneumonitis that required steroids, or current pneumonitis

No history of allergic reaction to the study agent(s) or compounds of similar chemical or biologic composition to the study agent(s) (or any of its excipients)

University of Alabama at Birmingham Cancer CenterNot yet recruiting

Birmingham, Alabama 35233, United States

Site Public ContactContact

gingerreeves@uabmc.edu

Charles A. LeathPrincipal Investigator

Highlands Oncology Group - FayettevilleRecruiting

Fayetteville, Arkansas 72703, United States

University of Arkansas for Medical SciencesRecruiting

Little Rock, Arkansas 72205, United States

Highlands Oncology Group - RogersRecruiting

Rogers, Arkansas 72758, United States

Highlands Oncology GroupRecruiting

Springdale, Arkansas 72762, United States

Kaiser Permanente-BellflowerRecruiting

Bellflower, California 90706, United States

City of Hope CoronaRecruiting

Corona, California 92882, United States

City of Hope Comprehensive Cancer CenterRecruiting

Duarte, California 91010, United States

Kaiser Permanente South BayRecruiting

Harbor City, California 90710, United States

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareRecruiting

Irvine, California 92612, United States

City of Hope at Irvine LennarRecruiting

Irvine, California 92618, United States

Kaiser Permanente-IrvineRecruiting

Irvine, California 92618, United States

UC San Diego Moores Cancer CenterRecruiting

La Jolla, California 92093, United States

City of Hope Antelope ValleySuspended

Lancaster, California 93534, United States

Kaiser Permanente Los Angeles Medical CenterRecruiting

Los Angeles, California 90027, United States

Kaiser Permanente West Los AngelesRecruiting

Los Angeles, California 90034, United States

UC Irvine Health/Chao Family Comprehensive Cancer CenterRecruiting

Orange, California 92868, United States

Kaiser Permanente - Panorama CityRecruiting

Panorama City, California 91402, United States

Kaiser Permanente-San Diego ZionRecruiting

San Diego, California 92120, United States

Kaiser Permanente-San MarcosRecruiting

San Marcos, California 92078, United States

City of Hope South PasadenaRecruiting

South Pasadena, California 91030, United States

City of Hope UplandRecruiting

Upland, California 91786, United States

Kaiser Permanente-Woodland HillsRecruiting

Woodland Hills, California 91367, United States

UCHealth University of Colorado HospitalRecruiting

Aurora, Colorado 80045, United States

UCHealth Highlands Ranch HospitalRecruiting

Highlands Ranch, Colorado 80129, United States

Danbury HospitalRecruiting

Danbury, Connecticut 06810, United States

Norwalk HospitalRecruiting

Norwalk, Connecticut 06856, United States

Beebe South Coastal Health CampusRecruiting

Millville, Delaware 19967, United States

Helen F Graham Cancer CenterRecruiting

Newark, Delaware 19713, United States

Medical Oncology Hematology Consultants PARecruiting

Newark, Delaware 19713, United States

Beebe Health CampusRecruiting

Rehoboth Beach, Delaware 19971, United States

UM Sylvester Comprehensive Cancer Center at Coral GablesRecruiting

Coral Gables, Florida 33146, United States

UM Sylvester Comprehensive Cancer Center at Coral SpringsRecruiting

Coral Springs, Florida 33065, United States

UM Sylvester Comprehensive Cancer Center at Deerfield BeachRecruiting

Deerfield Beach, Florida 33442, United States

UM Sylvester Comprehensive Cancer Center at DoralRecruiting

Doral, Florida 33166, United States

Broward Health Medical CenterRecruiting

Fort Lauderdale, Florida 33316, United States

Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting

Hollywood, Florida 33021, United States

UM Sylvester Comprehensive Cancer Center at HollywoodRecruiting

Hollywood, Florida 33021, United States

University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting

Miami, Florida 33136, United States

UM Sylvester Comprehensive Cancer Center at KendallRecruiting

Miami, Florida 33176, United States

Mount Sinai Medical CenterSuspended

Miami Beach, Florida 33140, United States

University of Miami Sylvester Comprehensive Cancer Center at Sole MiaRecruiting

North Miami, Florida 33181, United States

Health CentralRecruiting

Ocoee, Florida 34761, United States

Orlando Health Cancer InstituteRecruiting

Orlando, Florida 32806, United States

Memorial Hospital WestRecruiting

Pembroke Pines, Florida 33028, United States

UM Sylvester Comprehensive Cancer Center at PlantationRecruiting

Plantation, Florida 33324, United States

Moffitt Cancer Center at SouthShoreRecruiting

Ruskin, Florida 33570, United States

Moffitt Cancer Center-International PlazaRecruiting

Tampa, Florida 33607, United States

Moffitt Cancer Center - McKinley CampusRecruiting

Tampa, Florida 33612, United States

Moffitt Cancer CenterRecruiting

Tampa, Florida 33612, United States

Moffitt Cancer Center at Wesley ChapelRecruiting

Wesley Chapel, Florida 33544, United States

Emory University Hospital MidtownRecruiting

Atlanta, Georgia 30308, United States

Piedmont HospitalRecruiting

Atlanta, Georgia 30309, United States

Emory University Hospital/Winship Cancer InstituteRecruiting

Atlanta, Georgia 30322, United States

Emory Decatur HospitalRecruiting

Decatur, Georgia 30033, United States

CTCA at Southeastern Regional Medical CenterRecruiting

Newnan, Georgia 30265, United States

Saint Alphonsus Cancer Care Center-BoiseRecruiting

Boise, Idaho 83706, United States

Saint Luke's Cancer Institute - BoiseRecruiting

Boise, Idaho 83712, United States

Saint Alphonsus Cancer Care Center-CaldwellRecruiting

Caldwell, Idaho 83605, United States

Kootenai Health - Coeur d'AleneSuspended

Coeur d'Alene, Idaho 83814, United States

Saint Luke's Cancer Institute - FruitlandRecruiting

Fruitland, Idaho 83619, United States

Saint Luke's Cancer Institute - MeridianRecruiting

Meridian, Idaho 83642, United States

Saint Alphonsus Cancer Care Center-NampaRecruiting

Nampa, Idaho 83687, United States

Saint Luke's Cancer Institute - NampaRecruiting

Nampa, Idaho 83687, United States

Kootenai Clinic Cancer Services - Post FallsSuspended

Post Falls, Idaho 83854, United States

Northwestern UniversityRecruiting

Chicago, Illinois 60611, United States

Rush MD Anderson Cancer CenterRecruiting

Chicago, Illinois 60612, United States

University of IllinoisRecruiting

Chicago, Illinois 60612, United States

Carle at The RiverfrontRecruiting

Danville, Illinois 61832, United States

Cancer Care Specialists of Illinois - DecaturRecruiting

Decatur, Illinois 62526, United States

Decatur Memorial HospitalRecruiting

Decatur, Illinois 62526, United States

Northwestern Medicine Cancer Center KishwaukeeRecruiting

DeKalb, Illinois 60115, United States

Carle Physician Group-EffinghamRecruiting

Effingham, Illinois 62401, United States

Crossroads Cancer CenterSuspended

Effingham, Illinois 62401, United States

Northwestern Medicine Cancer Center DelnorRecruiting

Geneva, Illinois 60134, United States

Carle Physician Group-Mattoon/CharlestonRecruiting

Mattoon, Illinois 61938, United States

Loyola University Medical CenterRecruiting

Maywood, Illinois 60153, United States

Northwestern Medicine Oak BrookRecruiting

Oak Brook, Illinois 60523, United States

Northwestern Medicine Orland ParkRecruiting

Orland Park, Illinois 60462, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer CenterRecruiting

Peoria, Illinois 61615, United States

OSF Saint Francis Medical CenterRecruiting

Peoria, Illinois 61637, United States

UW Health Carbone Cancer Center RockfordRecruiting

Rockford, Illinois 61114, United States

Southern Illinois University School of MedicineRecruiting

Springfield, Illinois 62702, United States

Springfield ClinicRecruiting

Springfield, Illinois 62702, United States

Springfield Memorial HospitalRecruiting

Springfield, Illinois 62781, United States

Carle Cancer CenterRecruiting

Urbana, Illinois 61801, United States

Northwestern Medicine Cancer Center WarrenvilleRecruiting

Warrenville, Illinois 60555, United States

Midwestern Regional Medical CenterRecruiting

Zion, Illinois 60099, United States

IU Health North HospitalRecruiting

Carmel, Indiana 46032, United States

Northwest Cancer Center - Crown PointRecruiting

Crown Point, Indiana 46307, United States

Northwest Oncology LLCRecruiting

Dyer, Indiana 46311, United States

Parkview Regional Medical CenterRecruiting

Fort Wayne, Indiana 46845, United States

Northwest Cancer Center - HobartRecruiting

Hobart, Indiana 46342, United States

Saint Mary Medical CenterRecruiting

Hobart, Indiana 46342, United States

Indiana University/Melvin and Bren Simon Cancer CenterRecruiting

Indianapolis, Indiana 46202, United States

Sidney and Lois Eskenazi HospitalRecruiting

Indianapolis, Indiana 46202, United States

The Community HospitalRecruiting

Munster, Indiana 46321, United States

Women's Diagnostic Center - MunsterRecruiting

Munster, Indiana 46321, United States

Northwest Cancer Center - ValparaisoRecruiting

Valparaiso, Indiana 46383, United States

UI Health Care Mission Cancer and Blood - Ankeny ClinicRecruiting

Ankeny, Iowa 50023, United States

Mercy HospitalRecruiting

Cedar Rapids, Iowa 52403, United States

Oncology Associates at Mercy Medical CenterRecruiting

Cedar Rapids, Iowa 52403, United States

UI Health Care Mission Cancer and Blood - West Des Moines ClinicRecruiting

Clive, Iowa 50325, United States

Iowa Methodist Medical CenterRecruiting

Des Moines, Iowa 50309, United States

UI Health Care Mission Cancer and Blood - Des Moines ClinicRecruiting

Des Moines, Iowa 50309, United States

Mercy Medical Center - Des MoinesRecruiting

Des Moines, Iowa 50314, United States

UI Health Care Mission Cancer and Blood - Laurel ClinicRecruiting

Des Moines, Iowa 50314, United States

University of Iowa/Holden Comprehensive Cancer CenterRecruiting

Iowa City, Iowa 52242, United States

UI Health Care Mission Cancer and Blood - Waukee ClinicRecruiting

Waukee, Iowa 50263, United States

University of Kansas Cancer CenterRecruiting

Kansas City, Kansas 66160, United States

University of Kansas Cancer Center-Overland ParkRecruiting

Overland Park, Kansas 66210, United States

University of Kansas Hospital-Indian Creek CampusRecruiting

Overland Park, Kansas 66211, United States

University of Kansas Hospital-Westwood Cancer CenterRecruiting

Westwood, Kansas 66205, United States

University of Kentucky/Markey Cancer CenterRecruiting

Lexington, Kentucky 40536, United States

West Jefferson Medical CenterRecruiting

Marrero, Louisiana 70072, United States

East Jefferson General HospitalRecruiting

Metairie, Louisiana 70006, United States

LSU Healthcare Network / Metairie Multi-Specialty ClinicRecruiting

Metairie, Louisiana 70006, United States

University Medical Center New OrleansRecruiting

New Orleans, Louisiana 70112, United States

Ochsner Baptist Medical CenterRecruiting

New Orleans, Louisiana 70115, United States

Ochsner Medical Center JeffersonRecruiting

New Orleans, Louisiana 70121, United States

MaineHealth Coastal Cancer Treatment CenterRecruiting

Bath, Maine 04530, United States

MaineHealth Maine Medical Center - PortlandRecruiting

Portland, Maine 04102, United States

MaineHealth Cancer Care Center of York CountyRecruiting

Sanford, Maine 04073, United States

MaineHealth Maine Medical Center- ScarboroughRecruiting

Scarborough, Maine 04074, United States

University of Maryland/Greenebaum Cancer CenterRecruiting

Baltimore, Maryland 21201, United States

UM Upper Chesapeake Medical CenterRecruiting

Bel Air, Maryland 21014, United States

Central Maryland Radiation Oncology in Howard CountyRecruiting

Columbia, Maryland 21044, United States

University of Maryland Shore Medical Center at EastonRecruiting

Easton, Maryland 21601, United States

UM Baltimore Washington Medical Center/Tate Cancer CenterRecruiting

Glen Burnie, Maryland 21061, United States

UM Capital Region Medical CenterRecruiting

Largo, Maryland 20774, United States

UM Saint Joseph Medical CenterRecruiting

Towson, Maryland 21204, United States

Trinity Health Saint Joseph Mercy Hospital Ann ArborRecruiting

Ann Arbor, Michigan 48106, United States

University of Michigan Rogel Cancer CenterRecruiting

Ann Arbor, Michigan 48109, United States

Trinity Health Medical Center - BrightonRecruiting

Brighton, Michigan 48114, United States

University of Michigan - Brighton Center for Specialty CareRecruiting

Brighton, Michigan 48116, United States

Trinity Health Medical Center - CantonRecruiting

Canton, Michigan 48188, United States

Chelsea HospitalRecruiting

Chelsea, Michigan 48118, United States

Bronson Methodist HospitalRecruiting

Kalamazoo, Michigan 49007, United States

West Michigan Cancer CenterRecruiting

Kalamazoo, Michigan 49007, United States

University of Michigan Health - Sparrow LansingRecruiting

Lansing, Michigan 48912, United States

Trinity Health Saint Mary Mercy Livonia HospitalRecruiting

Livonia, Michigan 48154, United States

Trinity Health Saint Joseph Mercy Oakland HospitalSuspended

Pontiac, Michigan 48341, United States

Essentia Health Saint Joseph's Medical CenterRecruiting

Brainerd, Minnesota 56401, United States

Essentia Health - Deer River ClinicRecruiting

Deer River, Minnesota 56636, United States

Essentia Health Cancer CenterRecruiting

Duluth, Minnesota 55805, United States

Miller-Dwan HospitalRecruiting

Duluth, Minnesota 55805, United States

Essentia Health Hibbing ClinicRecruiting

Hibbing, Minnesota 55746, United States

Mayo Clinic in RochesterSuspended

Rochester, Minnesota 55905, United States

Regions HospitalRecruiting

Saint Paul, Minnesota 55101, United States

Essentia Health SandstoneRecruiting

Sandstone, Minnesota 55072, United States

Essentia Health Virginia ClinicRecruiting

Virginia, Minnesota 55792, United States

Freeman Health SystemRecruiting

Joplin, Missouri 64804, United States

University of Kansas Cancer Center - BriarcliffRecruiting

Kansas City, Missouri 64116, United States

University of Kansas Cancer Center - NorthRecruiting

Kansas City, Missouri 64154, United States

University of Kansas Cancer Center - Lee's SummitRecruiting

Lee's Summit, Missouri 64064, United States

Phelps Health Delbert Day Cancer InstituteRecruiting

Rolla, Missouri 65401, United States

Mercy Hospital SpringfieldRecruiting

Springfield, Missouri 65804, United States

Mercy Hospital Saint LouisRecruiting

St Louis, Missouri 63141, United States

Billings Clinic Cancer CenterRecruiting

Billings, Montana 59101, United States

Community Medical CenterSuspended

Missoula, Montana 59804, United States

Nebraska Methodist HospitalRecruiting

Omaha, Nebraska 68114, United States

University of Nebraska Medical CenterRecruiting

Omaha, Nebraska 68198, United States

Women's Cancer Center of NevadaRecruiting

Las Vegas, Nevada 89106, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterRecruiting

Lebanon, New Hampshire 03756, United States

Memorial Sloan Kettering Basking RidgeRecruiting

Basking Ridge, New Jersey 07920, United States

Cooper Hospital University Medical CenterRecruiting

Camden, New Jersey 08103, United States

Jersey City Medical CenterRecruiting

Jersey City, New Jersey 07302, United States

Monmouth Medical CenterRecruiting

Long Branch, New Jersey 07740, United States

Memorial Sloan Kettering MonmouthRecruiting

Middletown, New Jersey 07748, United States

Memorial Sloan Kettering BergenRecruiting

Montvale, New Jersey 07645, United States

Rutgers Cancer Institute of New JerseyRecruiting

New Brunswick, New Jersey 08903, United States

Rutgers New Jersey Medical SchoolRecruiting

Newark, New Jersey 07101, United States

Capital Health Medical Center-HopewellRecruiting

Pennington, New Jersey 08534, United States

Community Medical CenterRecruiting

Toms River, New Jersey 08755, United States

University of New Mexico Cancer CenterRecruiting

Albuquerque, New Mexico 87106, United States

Northwell Health Imbert Cancer CenterRecruiting

Bay Shore, New York 11706, United States

Roswell Park Cancer InstituteRecruiting

Buffalo, New York 14263, United States

Memorial Sloan Kettering CommackRecruiting

Commack, New York 11725, United States

Northwell Health Physician Partners at FlushingRecruiting

Flushing, New York 11354, United States

Northwell Health Physicians Partners Radiation Medicine at QueensRecruiting

Forest Hills, New York 11375, United States

Northwell Health Cancer Institute at HuntingtonRecruiting

Greenlawn, New York 11740, United States

Memorial Sloan Kettering WestchesterRecruiting

Harrison, New York 10604, United States

Northwell Health/Center for Advanced MedicineRecruiting

Lake Success, New York 11042, United States

NYU Langone Hospital - Long IslandRecruiting

Mineola, New York 11501, United States

Northern Westchester HospitalRecruiting

Mount Kisco, New York 10549, United States

Mount Sinai ChelseaRecruiting

New York, New York 10011, United States

Laura and Isaac Perlmutter Cancer Center at NYU LangoneRecruiting

New York, New York 10016, United States

Mount Sinai HospitalRecruiting

New York, New York 10029, United States

Manhattan Eye Ear and Throat HospitalRecruiting

New York, New York 10065, United States

Memorial Sloan Kettering Cancer CenterRecruiting

New York, New York 10065, United States

Lenox Hill HospitalRecruiting

New York, New York 10075, United States

Upstate Cancer Center Radiation Oncology at OswegoRecruiting

Oswego, New York 13126, United States

Queens Cancer CenterRecruiting

Rego Park, New York 11374, United States

Phelps Memorial Hospital CenterRecruiting

Sleepy Hollow, New York 10591, United States

Staten Island University HospitalRecruiting

Staten Island, New York 10305, United States

Stony Brook University Medical CenterRecruiting

Stony Brook, New York 11794, United States

State University of New York Upstate Medical UniversityRecruiting

Syracuse, New York 13210, United States

Upstate Cancer Center at Hill Radiation OncologyRecruiting

Syracuse, New York 13210, United States

Montefiore Medical Center-Einstein CampusRecruiting

The Bronx, New York 10461, United States

Montefiore Medical Center-Weiler HospitalRecruiting

The Bronx, New York 10461, United States

Montefiore Medical Center - Moses CampusRecruiting

The Bronx, New York 10467, United States

Memorial Sloan Kettering NassauRecruiting

Uniondale, New York 11553, United States

Upstate Cancer Center at VeronaRecruiting

Verona, New York 13478, United States

UNC Lineberger Comprehensive Cancer CenterRecruiting

Chapel Hill, North Carolina 27599, United States

Carolinas Medical Center/Levine Cancer InstituteRecruiting

Charlotte, North Carolina 28203, United States

Novant Health Presbyterian Medical CenterRecruiting

Charlotte, North Carolina 28204, United States

Atrium Health Cabarrus/LCI-ConcordRecruiting

Concord, North Carolina 28025, United States

Duke University Medical CenterRecruiting

Durham, North Carolina 27710, United States

Levine Cancer Institute-GastonRecruiting

Gastonia, North Carolina 28054, United States

Novant Health Cancer Institute - HuntersvilleRecruiting

Huntersville, North Carolina 28078, United States

Novant Health Cancer Institute - KernersvilleRecruiting

Kernersville, North Carolina 27284, United States

Matthews Radiation Oncology CenterRecruiting

Matthews, North Carolina 28105, United States

Duke Women's Cancer Care RaleighRecruiting

Raleigh, North Carolina 27607, United States

Novant Cancer Institute Radiation Oncology - SupplyRecruiting

Supply, North Carolina 28462, United States

Novant Health Cancer Institute Radiation Oncology - WilmingtonRecruiting

Wilmington, North Carolina 28401, United States

Novant Health New Hanover Regional Medical CenterRecruiting

Wilmington, North Carolina 28401, United States

Novant Health Forsyth Medical CenterRecruiting

Winston-Salem, North Carolina 27103, United States

Wake Forest University Health SciencesRecruiting

Winston-Salem, North Carolina 27157, United States

UHHS-Chagrin Highlands Medical CenterRecruiting

Beachwood, Ohio 44122, United States

Aultman Health FoundationRecruiting

Canton, Ohio 44710, United States

Miami Valley Hospital SouthRecruiting

Centerville, Ohio 45459, United States

Geauga HospitalRecruiting

Chardon, Ohio 44024, United States

University of Cincinnati Cancer Center-UC Medical CenterRecruiting

Cincinnati, Ohio 45219, United States

Case Western Reserve UniversityRecruiting

Cleveland, Ohio 44106, United States

Cleveland Clinic FoundationRecruiting

Cleveland, Ohio 44195, United States

Ohio State University Comprehensive Cancer CenterRecruiting

Columbus, Ohio 43210, United States

Miami Valley HospitalRecruiting

Dayton, Ohio 45409, United States

Miami Valley Hospital NorthRecruiting

Dayton, Ohio 45415, United States

Atrium Medical Center-Middletown Regional HospitalRecruiting

Franklin, Ohio 45005-1066, United States

Miami Valley Cancer Care and InfusionRecruiting

Greenville, Ohio 45331, United States

Hillcrest Hospital Cancer CenterRecruiting

Mayfield Heights, Ohio 44124, United States

UH Seidman Cancer Center at Lake Health Mentor CampusRecruiting

Mentor, Ohio 44060, United States

University Hospitals Parma Medical CenterRecruiting

Parma, Ohio 44129, United States

ProMedica Flower HospitalRecruiting

Sylvania, Ohio 43560, United States

Upper Valley Medical CenterRecruiting

Troy, Ohio 45373, United States

University of Cincinnati Cancer Center-West ChesterRecruiting

West Chester, Ohio 45069, United States

UH Seidman Cancer Center at Saint John Medical CenterRecruiting

Westlake, Ohio 44145, United States

University of Oklahoma Health Sciences CenterRecruiting

Oklahoma City, Oklahoma 73104, United States

Oklahoma Cancer Specialists and Research Institute-TulsaRecruiting

Tulsa, Oklahoma 74146, United States

Clackamas Radiation Oncology CenterRecruiting

Clackamas, Oregon 97015, United States

Providence Newberg Medical CenterRecruiting

Newberg, Oregon 97132, United States

Providence Willamette Falls Medical CenterRecruiting

Oregon City, Oregon 97045, United States

Legacy Good Samaritan Hospital and Medical CenterRecruiting

Portland, Oregon 97210, United States

Providence Portland Medical CenterRecruiting

Portland, Oregon 97213, United States

Providence Saint Vincent Medical CenterRecruiting

Portland, Oregon 97225, United States

Kaiser Permanente NorthwestRecruiting

Portland, Oregon 97227, United States

Oregon Health and Science UniversityRecruiting

Portland, Oregon 97239, United States

Legacy Meridian Park HospitalRecruiting

Tualatin, Oregon 97062, United States

Lehigh Valley Hospital-Cedar CrestRecruiting

Allentown, Pennsylvania 18103, United States

Saint Luke's Cancer Center - AllentownRecruiting

Allentown, Pennsylvania 18104, United States

Saint Luke's University Hospital-Bethlehem CampusRecruiting

Bethlehem, Pennsylvania 18015, United States

Lehigh Valley Hospital - MuhlenbergRecruiting

Bethlehem, Pennsylvania 18017, United States

Geisinger Medical CenterRecruiting

Danville, Pennsylvania 17822, United States

Geisinger Cancer Center Dickson CityRecruiting

Dickson City, Pennsylvania 18519, United States

Pocono Medical CenterRecruiting

East Stroudsburg, Pennsylvania 18301, United States

Saint Luke's Hospital-Anderson CampusRecruiting

Easton, Pennsylvania 18045, United States

UPMC Hillman Cancer Center ErieRecruiting

Erie, Pennsylvania 16505, United States

UPMC Cancer Centers - Arnold Palmer PavilionRecruiting

Greensburg, Pennsylvania 15601, United States

UPMC Pinnacle Cancer Center/Community Osteopathic CampusRecruiting

Harrisburg, Pennsylvania 17109, United States

Penn State Milton S Hershey Medical CenterRecruiting

Hershey, Pennsylvania 17033-0850, United States

IRMC Cancer CenterRecruiting

Indiana, Pennsylvania 15701, United States

Jefferson HospitalRecruiting

Jefferson Hills, Pennsylvania 15025, United States

UPMC-Johnstown/John P. Murtha Regional Cancer CenterRecruiting

Johnstown, Pennsylvania 15901, United States

Geisinger Medical Oncology-LewisburgRecruiting

Lewisburg, Pennsylvania 17837, United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionRecruiting

Mechanicsburg, Pennsylvania 17050, United States

Forbes HospitalRecruiting

Monroeville, Pennsylvania 15146, United States

Thomas Jefferson University HospitalRecruiting

Philadelphia, Pennsylvania 19107, United States

Fox Chase Cancer CenterRecruiting

Philadelphia, Pennsylvania 19111, United States

Temple University HospitalRecruiting

Philadelphia, Pennsylvania 19140, United States

Allegheny General HospitalRecruiting

Pittsburgh, Pennsylvania 15212, United States

UPMC-Magee Womens HospitalRecruiting

Pittsburgh, Pennsylvania 15213, United States

West Penn HospitalRecruiting

Pittsburgh, Pennsylvania 15224, United States

UPMC-Passavant HospitalRecruiting

Pittsburgh, Pennsylvania 15237, United States

Saint Luke's Hospital - Upper Bucks CampusRecruiting

Quakertown, Pennsylvania 18951, United States

UPMC Cancer Center at UPMC NorthwestRecruiting

Seneca, Pennsylvania 16346, United States

Saint Luke's Hospital - Monroe CampusRecruiting

Stroudsburg, Pennsylvania 18360, United States

Wexford Health and Wellness PavilionRecruiting

Wexford, Pennsylvania 15090, United States

Geisinger Wyoming Valley/Henry Cancer CenterRecruiting

Wilkes-Barre, Pennsylvania 18711, United States

Asplundh Cancer PavilionRecruiting

Willow Grove, Pennsylvania 19090, United States

Women and Infants HospitalRecruiting

Providence, Rhode Island 02905, United States

Medical University of South CarolinaRecruiting

Charleston, South Carolina 29425, United States

Gibbs Cancer Center-GaffneyRecruiting

Gaffney, South Carolina 29341, United States

Gibbs Cancer Center-PelhamRecruiting

Greer, South Carolina 29651, United States

Spartanburg Medical CenterRecruiting

Spartanburg, South Carolina 29303, United States

Avera Cancer InstituteRecruiting

Sioux Falls, South Dakota 57105, United States

Parkland Memorial HospitalRecruiting

Dallas, Texas 75235, United States

UT Southwestern/Simmons Cancer Center-DallasRecruiting

Dallas, Texas 75390, United States

UT Southwestern/Simmons Cancer Center-Fort WorthRecruiting

Fort Worth, Texas 76104, United States

UT Southwestern Clinical Center at Richardson/PlanoRecruiting

Richardson, Texas 75080, United States

Farmington Health CenterRecruiting

Farmington, Utah 84025, United States

University of Utah Sugarhouse Health CenterRecruiting

Salt Lake City, Utah 84106, United States

Huntsman Cancer Institute/University of UtahRecruiting

Salt Lake City, Utah 84112, United States

Inova Alexandria HospitalRecruiting

Alexandria, Virginia 22304, United States

University of Virginia Cancer CenterRecruiting

Charlottesville, Virginia 22908, United States

Inova Schar Cancer InstituteRecruiting

Fairfax, Virginia 22031, United States

Inova Fair Oaks HospitalRecruiting

Fairfax, Virginia 22033, United States

Inova Fairfax HospitalRecruiting

Falls Church, Virginia 22042, United States

Inova Loudoun HospitalRecruiting

Leesburg, Virginia 20176, United States

VCU Massey Comprehensive Cancer CenterRecruiting

Richmond, Virginia 23298, United States

Carilion Roanoke Memorial HospitalRecruiting

Roanoke, Virginia 24033, United States

Fred Hutchinson Cancer CenterRecruiting

Seattle, Washington 98109, United States

Legacy Salmon Creek HospitalRecruiting

Vancouver, Washington 98686, United States

West Virginia University Charleston DivisionRecruiting

Charleston, West Virginia 25304, United States

West Virginia University HealthcareRecruiting

Morgantown, West Virginia 26506, United States

Camden Clark Medical CenterRecruiting

Parkersburg, West Virginia 26101, United States

Duluth Clinic AshlandRecruiting

Ashland, Wisconsin 54806, United States

Northwest Wisconsin Cancer CenterRecruiting

Ashland, Wisconsin 54806, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterRecruiting

Madison, Wisconsin 53718, United States

University of Wisconsin Carbone Cancer Center - University HospitalRecruiting

Madison, Wisconsin 53792, United States

Medical College of WisconsinRecruiting

Milwaukee, Wisconsin 53226, United States

ProHealth D N Greenwald CenterRecruiting

Mukwonago, Wisconsin 53149, United States

Cancer Center of Western WisconsinRecruiting

New Richmond, Wisconsin 54017, United States

ProHealth Oconomowoc Memorial HospitalRecruiting

Oconomowoc, Wisconsin 53066, United States

Essentia Health Saint Mary's Hospital - SuperiorRecruiting

Superior, Wisconsin 54880, United States

UW Cancer Center at ProHealth CareRecruiting

Waukesha, Wisconsin 53188, United States