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| Name | Class |
|---|---|
| Patient-Centered Outcomes Research Institute | OTHER |
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Alcohol use is prevalent in U.S. adolescents and contributes to adverse health outcomes in this population. Care for adolescent alcohol use is lacking in most pediatric primary care settings (PPC). This project is a pragmatic comparative effectiveness and implementation study that employs a superiority, two-arm, randomized, prospective, observer-blinded, controlled trial design to compare the effectiveness of a patient-centered brief motivational interviewing-based alcohol intervention (BMAI) alone to the same BMAI augmented with adjunctive smartphone app-delivered mindfulness training (MT) for alcohol use in adolescents receiving primary care in PPC clinics across a regional health network. Main effectiveness outcomes will be alcohol use and alcohol related problems assessed over a one-year follow-up period. Implementation outcomes and mediators and moderators of intervention response will also be examined as part of the study.
Alcohol use is prevalent in U.S. adolescents and contributes to adverse health outcomes in this population. Over the past decade, screening, brief intervention, and referral to treatment (SBIRT) has become the primary model for addressing alcohol problems in US adolescents in pediatric healthcare settings. However, uptake and fidelity of SBIRT vary widely in real world settings and barriers to implementing effective brief interventions are common. Standard brief alcohol interventions (BAIs) have predominantly applied motivational interviewing (MI) and feedback techniques to target alcohol and other drug use in adolescents. There is a need to expand BAI options for youth who do not respond to these standard approaches. One intervention approach with growing societal interest and emerging evidence for efficacy in adolescent alcohol and other drug use is mindfulness training (MT). This project will compare two types of evidenced-based care for alcohol use in adolescents recruited from 13 pediatric primary care clinics in a regional health system. The interventions will be a patient-centered brief motivational interviewing-based alcohol intervention (BMAI) delivered by PPC clinicians as part of routine care, and BMAI in combination with smartphone app-delivered mindfulness training (BMAI+ MT).
The project is a pragmatic effectiveness and implementation study that employs a superiority, two-arm, randomized, prospective, observer-blinded, controlled trial design to compare the effectiveness of BMAI alone vs. BMAI augmented with adjunctive smartphone app-delivered MT on alcohol outcomes over a one-year follow-up period. The investigators will use the well-established standard BMAI adapted from the Provider Guide: Adolescent SBIRT Using the Screening to Brief Intervention Car, Relax, Alone, Forget, Friends, Trouble (S2BI-CRAFFT) Screening Tool, an evidence-based brief intervention for alcohol use in youth, and the widely disseminated Healthy Minds Program (HMP) smartphone meditation/mindfulness app which is freely available, science-based, and has shown feasibility and efficacy for reducing stress in youth populations. These interventions which combine elements of face-to-face +/- digital delivery and MI +/- MT will be tested in PPC clinics throughout the Johns Hopkins Medical Institute (JHMI) healthcare network which primarily serves racially/ethnically diverse population of urban and suburban youth in the greater Baltimore/Washington region that has a high proportion of minoritized youth.
The project seeks to answer the following three research questions:
Comparative effectiveness outcomes: What is the relative effectiveness of face-to-face clinician-administered BMAI with vs. without adjunctive app-delivered MT with the HMP app for alcohol using youth in PPC settings? Does supplementing clinician-administered BMAI with app-delivered MT result in superior outcomes in the form of reduced alcohol use and problems for this population or subgroups of the population?
Implementation outcomes: What are the patient and stakeholder perspectives, experiences, and preferences related to delivering BAI with these different components? What are the barriers and facilitators to delivering these BAI in PPC settings and for the diverse patient population served?
Heterogeneity of treatment effect (HTE) outcomes: How do baseline factors such as clinical severity, comorbid psychiatric symptoms and conditions, Socio-economic status (SES), sex, race, ethnicity, caregiver involvement, treatment preference, organization and clinical site readiness, and level of SBIRT integration at PPC clinic sites moderate outcomes across comparator interventions? How do changes in factors that may be mechanism of behavioral change (MOBC) for the different interventions (e.g. 'intrinsic' motivation to quit/reduce drinking, self-efficacy, and goal commitment for MI and mindfulness, anxiety, depression, impulsivity, and self-regulation for MT) and degree of engagement with intervention components (e.g., no. of sessions attended, time spent and no. of MT exercises completed, application of mindfulness in real-life settings) mediate outcomes across comparator interventions? Which patient subgroups benefit the most from which specific mindfulness and motivational BAI components?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Brief Motivational interviewing-based Alcohol Intervention (BMAI) | Active Comparator | Participants randomized to this arm will receive a brief motivational interviewing-based alcohol intervention (BMAI) delivered in person by a pediatric clinician in the pediatric primary care (PPC) office setting. BMAI is adapted from the Provider Guide: Adolescent SBIRT Using the S2BI-CRAFFT Screening Tool and incorporates motivational interviewing (MI) principles. It includes clinician-delivered feedback, advice, and goal setting to help adolescents recognize links between alcohol/drug use and negative health outcomes, and to develop personalized change plans. BMAI is delivered across one or more visits, with the initial session typically lasting 10-30 minutes and follow-ups lasting 5-15 minutes. Clinicians delivering BMAI include pediatricians, nurses, and social workers who provide primary care to 12-17-year-olds at participating JHMI sites and who have completed SBIRT/BMAI training and monitoring as part of the trial. |
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| BMAI + Smartphone app-delivered Mindfulness Training (BMAI + MT) | Active Comparator | Participants randomized to this arm will receive the BMAI intervention described above plus 8 weeks of adjunctive smartphone-delivered mindfulness training (MT) via the Healthy Minds Program (HMP) app. The HMP app offers self-guided, self-paced mindfulness and meditation training, with core modules on Awareness, Insight, Connection, and Purpose. This study focuses on the Awareness and Insight modules, which teach breath and body awareness, noting of emotions, and the application of mindfulness in daily life. After randomization, participants will meet with study staff to download the app, receive instruction, and be asked to use it 5-30 minutes daily, following a pathway of 4 weeks of Awareness content, then 4 weeks of Insight content. After the 8-week MT period, participants will have open access to all HMP modules and be encouraged to explore the remaining content as desired during the follow-up period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brief Motivational Interviewing-based Alcohol Intervention | Behavioral | Participants in both arms (BMAI and BMAI + MT) will receive a brief motivational interviewing-based alcohol intervention (BMAI) delivered by a pediatric clinician in the primary care setting. BMAI is adapted from the Provider Guide: Adolescent SBIRT Using the S2BI-CRAFFT Screening Tool, grounded in the stages of change model and motivational interviewing (MI). It consists of one or more brief sessions involving structured feedback, advice, and goal setting to help adolescents recognize links between substance use and health outcomes and develop personalized change plans. The intervention is face-to-face, delivered during routine or follow-up visits, and modeled after the brief negotiated interview. The first session lasts 10-30 minutes and includes six MI-based steps. This is followed by one or more additional brief MI sessions lasting 5-15 minutes where the patient's goals are reviewed, gains or barriers are addressed, and ongoing support is provided. |
| Measure | Description | Time Frame |
|---|---|---|
| Alcohol Use (total standard drinks) in the past 30 days | Alcohol use (total standard drinks) in the past 30 days, measured via Timeline Follow Back (TLFB) calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Acceptability of intervention (adolescent report) assessed by the Client Satisfaction Questionnaire-Patient Report | Adolescent reported acceptability of BMAI and MT intervention components will be assessed via the Client Satisfaction Questionnaire-Patient Report (CSQ-Patient Report) collected at month 2. CSQ Patient Report scale ranges from 0 to 32 with higher scores indicating greater satisfaction with the intervention. | Month 2 |
| Acceptability of intervention (caregiver report) assessed by the Client Satisfaction Questionnaire-Caregiver Report | Caregiver reported acceptability of BMAI and MT components will be assessed via the Client Satisfaction Questionnaire-Caregiver Report (CSQ-Caregiver Report) at month 2. CSQ Caregiver Report scale ranges from 0 to 32 with higher scores indicating greater satisfaction with the intervention. | Month 2 |
| Acceptability of intervention (provider report) assessed by the Provider Satisfaction Questionnaire | Provider reported acceptability of BMAI and MT components will be assessed via the Provider Satisfaction Questionnaire (PSQ), an adapted form of the Client Satisfaction Questionnaire at month 3 and month 12. PSQ scale ranges from 0 to 32 with higher scores indicating greater satisfaction with the intervention. | month 3, and month 12 |
| Intervention experiences, perspectives, and preferences (adolescent report) assessed by qualitative interview |
| Measure | Description | Time Frame |
|---|---|---|
| Heavy episodic drinking (HED) days in the past 30 days | Heavy episodic drinking days in the past 30 days (defined as number of days in the past 30 days where participant consumed > 5 drinks for male and > 4 drinks for female participants in single session), measured via TLFB calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Drinking to Cope (DTC) with negative emotions assessed by the 5 item Coping Subscale | Drinking to Cope (DTC) with negative emotions assessed with the 5-item Coping Subscale of the Drinking Motives Questionnaire-Revised (DMQ-R) at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The DTC subscale ranges from 5 to 25 with higher scores indicating greater coping motives for alcohol use. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christopher J Hammond, MD, PhD | Contact | (410) 550-0144 | chammo20@jhmi.edu | |
| Gabrielle Newton, MPH | Contact | gnewton3@jh.edu |
| Name | Affiliation | Role |
|---|---|---|
| Christopher J Hammond, MD, PhD | Johns Hopkins University | Principal Investigator |
| Hoover Adger, MD, MPH, MBA | Johns Hopkins University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins Community Physicians, Remington | Not yet recruiting | Baltimore | Maryland | 21211 | United States | |
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Participants are assigned to one of two or more groups in parallel for the duration of the study
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Research Assistant who is collecting patient data.
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| Smartphone App-delivered Mindfulness Training | Behavioral | In addition to BMAI, participants in the BMAI + MT arm will receive 8 weeks of smartphone-delivered mindfulness training using the Healthy Minds Program (HMP) app. The HMP app provides self-guided, self-paced mindfulness and meditation training designed to improve psychological well-being, reduce stress/anxiety, and enhance self-regulation. It includes podcast-style teachings and guided meditations. The app features four modules-Awareness, Insight, Connection, and Purpose-based on neuroscience research. Each module offers 27 practices (5-30 minutes each). This study focuses on the Awareness and Insight modules, which teach breath and body awareness and emotion noting to support mindfulness in daily life. Participants will be asked to use the app 5-30 minutes per day, following 4 weeks of Awareness content, then 4 weeks of Insight. After 8 weeks, they will have open access to all modules and be encouraged to explore additional practices as they find helpful during follow-up. |
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Adolescent reported personal experiences, perspectives, and preferences related to BMAI and MT components, assessed via qualitative semi-structured interviews obtained from adolescent participants at 2 months. Themes and sub-themes using a grounded theory, inductive approach will be used to identify patient experience with the study arms and interventions.
| Month 2 |
| Intervention experiences, perspectives, and preferences (caregiver report) assessed by qualitative interview | Caregiver reported personal experiences, perspectives, and preferences related to BMAI and MT components, assessed via qualitative semi-structured interviews obtained from caregiver's of adolescent participants at 2 months. Themes and sub-themes using a grounded theory, inductive approach will be used to identify patient experience with the study arms and interventions. | Month 2 |
| Intervention experiences, perspectives, and preferences (provider report) assessed by qualitative interview | Provider reported personal experiences, perspectives, and preferences related to BMAI and MT components, assessed via qualitative semi-structured interviews obtained from pediatric primary care (PPC) providers obtained at months 3 and 12. Themes and sub-themes using a grounded theory, inductive approach will be used to identify patient experience with the study arms and interventions. | month 3, and month 12 |
| Implementation barriers and facilitators for SBIRT and BMAI (provider report) | Provider reported barriers and facilitators related to implementation of BMAI intervention and screening brief intervention and referral to treatment (SBIRT) framework, assessed using items about perceived barriers and facilitators from the SBIRT provider questionnaire obtained from PPC clinicians at baseline, month 3, and month 12. The SBIRT provider questionnaire includes questions on substance use screening, brief intervention, and SBIRT practices and perceived barriers and facilitators to screening, providing brief interventions, and implementing SBIRT in their PPC office setting. Number of barriers, number of facilitators, and percentage of providers reporting specific types of barriers and facilitators will be serve as the implementation outcome. | Baseline, month 3, and month 12 |
| Percentage of providers reporting barriers and facilitators (provider report) | Percentage of providers reporting specific types of barriers and facilitators will serve as the implementation outcome. | Baseline, month 3, and month 12 |
| Baseline, 1, 3, 6, and 12 months |
| Cannabis use days in the past 30 days | Cannabis/ tetrahydrocannabinol (THC) product use days in the past 30 days, measured via TLFB calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Tobacco/nicotine use days in the past 30 days | Tobacco/nicotine product use days in the past 30 days, measured via TLFB calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Other drug use days in the past 30 days | Other drug use days in the past 30 days (defined as number of days in the past 30 days where drugs other than alcohol, cannabis, tobacco/nicotine were used), measured via TLFB calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Alcohol-related problem severity assessed by the Alcohol Use Disorders Identification Test | Alcohol-related problem severity measured via the Alcohol Use Disorders Identification Test consumption questions (AUDIT-C) at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The AUDIT-C consists of 3 items assessing typical drinking frequency, typical drinking quantity, and frequency of heavy episodic drinking, each scored from 0 to 4. The AUDIT-C composite score has a scale that ranges from 0 to 12 with higher scores indicating greater alcohol problem severity. A total AUDIT-C score > or equal to 3 has a good sensitivity and specificity for detecting alcohol use problems in adolescents. | Baseline, 1, 3, 6, and 12 months |
| Recent Alcohol Consumption (past 7 days) | Recent alcohol consumption (defined as total number of standard drinks in the past 7 days), measured via TLFB calendar method at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Alcohol-related consequences assessed by the Short Index of Problems | Alcohol-related consequences assessed with the Short Index of Problems (SIP) related to alcohol consumption at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The SIP consists of 17 questions each scored from 0 to 3. The scale ranges from 0 to 51 with higher scores indicating greater occurrence of alcohol related negative consequences. | Baseline, 1, 3, 6, and 12 months |
| Emergency health service utilization | Emergency health service utilization (defined as the number of visits to the emergency room for health treatment), measured via 1-item on emergency department visits from The Economic Form-90 at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. | Baseline, 1, 3, 6, and 12 months |
| Quality of Life (QOL) as assessed by the Patient Reported Outcomes Measurement Information System (PROMIS) | Quality of Life (QOL) assessed with the Patient-Reported Outcomes Measurement Information System (PROMIS) pediatric global health (PGH-7) index at five time points (baseline and 1, 2, 3, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups.The PROMIS PGH-7 index consists of 7 questions each scored from 1 to 5. The scale ranges from 7 to 35 with higher scores indicating greater QOL and general health. | Baseline, 1, 3, 6, and 12 months |
| Baseline, 1, 3, 6, and 12 months |
| Alcohol Cravings assessed by the 5 item Penn Alcohol Craving scale | Alcohol cravings assessed with the 5-Item Penn Alcohol Craving Scale (PACS) at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The PACS scale ranges from 0 to 30 with higher scores indicating greater cravings for alcohol use in the past week. | Baseline, 1, 3, 6, and 12 months |
| Dispositional Mindfulness assessed by the10 item Child and Adolescent Mindfulness Measure | Dispositional Mindfulness assessed with the 10-Item Child and Adolescent Mindfulness Measure (CAAM), at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The CAAM scale ranges from 0 to 40 with higher scores indicating greater levels of dispositional mindfulness. Dispositional mindfulness at baseline and change in dispositional mindfulness during/following treatment will be examined as potential moderators and mediators of BMAI vs. BMAI + MT intervention effects on alcohol outcomes, respectively. | Baseline, 1, 3, 6, and 12 months |
| Mindfulness Practice assessed by Applied Mindfulness Process Scale | Mindfulness practice (defined as use of mindfulness skills in day-to-day life) assessed with the Applied Mindfulness Process Scale (AMPS), at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The AMPS scale ranges from 0 to 60 with higher scores indicating greater application of mindfulness skills in daily life coinciding with mindfulness practice. Mindfulness practice will be examined as a potential mediator of BMAI vs. BMAI + MT intervention effects on alcohol outcomes. | Baseline, 1, 3, 6, and 12 months |
| Healthy Mind Program (HMP) App Usage | Healthy Minds Program (HMP) mindfulness app usage data on the number of completed HMP practices/exercises, modules used, will be collected from each participant in the BMAI + MT group. This app usage data will be examined as a potential mediator of BMAI vs. BMAI + MT intervention effects on alcohol outcomes. | 1, 3, 6, and 12 months |
| Healthy Mind Program (HMP) App Usage (time spent) | Healthy Minds Program (HMP) mindfulness app usage data on the time spent (minutes) using the HMP app will be collected from each participant in the BMAI + MT group. This app usage data will be examined as a potential mediator of BMAI vs. BMAI + MT intervention effects on alcohol outcomes. | 1, 3, 6, and 12 months |
| Healthy Mind Program (HMP) App Usage (days of usage) | Healthy Minds Program (HMP) mindfulness app usage data on the days spent using the HMP app will be collected from each participant in the BMAI + MT group. This app usage data will be examined as a potential mediator of BMAI vs. BMAI + MT intervention effects on alcohol outcomes. | 1, 3, 6, and 12 months |
| Healthy Mind Program (HMP) Proportion of participant usage | Aggregate app use data (proportion of participants in the BMAI + MT group completing 50%, 75%, and 100% of HMP exercises and modules) will serve as an index of app uptake and engagement for the study. | 1, 3, 6, and 12 months |
| Depression assessed by the Patient Health Questionnaire for Adolescents | Depression assessed with the Patient Health Questionnaire for Adolescents (PHQ-9-A) at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The PHQ-9-A scale ranges from 0 to 27 with higher scores indicating higher depression severity. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe depression, respectively. A total PHQ-9-A score > 10 has a good sensitivity and specificity for Major Depressive Disorder in adolescents in PPC. Depression at baseline and change in depression severity during/following treatment will be examined as potential moderators and mediators of BMAI vs. BMAI + MT intervention effects on alcohol outcomes. | Baseline, 1, 3, 6, and 12 months |
| Anxiety assessed by the Generalized Anxiety Disorder Scale | Anxiety assess with the Generalized anxiety disorder (GAD-7) scale at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The GAD-7 scale ranges from 0 to 21 with higher scores indicating higher anxiety severity. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. A total GAD-7 score > 10 has a good sensitivity and specificity for Generalized Anxiety Disorder among adolescents in PPC. Anxiety at baseline and change in anxiety severity during/following treatment will be examined as potential moderators and mediators of BMAI vs. BMAI + MT intervention effects on alcohol outcomes, respectively. | Baseline, 1, 3, 6, and 12 months |
| Impulsivity assessed by the Short-version of the Urgency Pre-meditation Perseverance Sensation Seeking Positive Urgency | Impulsivity assessed with the Short-Version of the Urgency-Premeditation-Perseverance-Sensation Seeking-Positive Urgency (UPPS-P) negative urgency subscale at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The negative urgency subscale of the UPPS-P consists of 4 items scored from 1 to 4. The subscale ranges from 4 to 16 with higher scores indicating a greater tendency to act impulsively or rashly when experiencing negative emotions. Impulsivity at baseline and change in impulsivity during/following treatment will be examined as potential moderators and mediators of BMAI vs. BMAI + MT intervention effects on alcohol outcomes, respectively. | Baseline, 1, 3, 6, and 12 months |
| Emotion Regulation assessed by the16 item Brief Version of the Difficulties in Emotion Regulation Scale | Emotion regulation assessed with the 16-item Brief Version of the Difficulties in Emotion Regulation Scale (DERS-16) at five time points (baseline and 1, 3, 6, and 12 months) over a one year follow-up period, compared between BMAI and BMAI + MT groups. The DERS-16 scale ranges from 16 to 80 with higher scores indicating greater levels of emotion dysregulation. Emotion regulation at baseline and change in emotion regulation during/following treatment will be examined as potential moderators and mediators of BMAI vs. BMAI + MT intervention effects on alcohol outcomes, respectively. | Baseline, 1, 3, 6, and 12 months |
| Johns Hopkins Bayview Pediatrics (Baltimore Medical System, Yard 56) |
| Not yet recruiting |
| Baltimore |
| Maryland |
| 21224 |
| United States |
| Johns Hopkins Community Physicians, Canton Crossing | Not yet recruiting | Baltimore | Maryland | 21224 | United States |
| Harriet Lane Clinic | Recruiting | Baltimore | Maryland | 21287 | United States |
| Johns Hopkins University Center for Adolescent and Young Adult Health | Recruiting | Baltimore | Maryland | 21287 | United States |
| Johns Hopkins Community Physicians, Water's Edge | Not yet recruiting | Belcamp | Maryland | 21017 | United States |
| Johns Hopkins Community Physicians, Bowie | Not yet recruiting | Bowie | Maryland | 20715 | United States |
| Johns Hopkins Community Physicians, Howard County Pediatrics | Not yet recruiting | Columbia | Maryland | 21046 | United States |
| Johns Hopkins Community Physicians, Glen Burnie | Not yet recruiting | Glen Burnie | Maryland | 20161 | United States |
| Johns Hopkins Community Physicians, Hagerstown | Not yet recruiting | Hagerstown | Maryland | 21742 | United States |
| Johns Hopkins Community Physicians, White Marsh Pediatrics | Not yet recruiting | Nottingham | Maryland | 21236 | United States |
| Johns Hopkins Community Physicians, Odenton Medical | Not yet recruiting | Odenton | Maryland | 21113 | United States |
| Johns Hopkins Community Physicians, Rockville Pediatrics | Not yet recruiting | Rockville | Maryland | 20854 | United States |
| ID | Term |
|---|---|
| D000066608 | Underage Drinking |
| D000428 | Alcohol Drinking |
| ID | Term |
|---|---|
| D000294 | Adolescent Behavior |
| D001519 | Behavior |
| D004327 | Drinking Behavior |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| D008722 | Methods |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D008919 | Investigative Techniques |
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