A Study of Carbon 13-based Deep Labelling of Bone Marrow Cells

A Pilot Study of 13Carbon-Based Deep Labeling of Bone Marrow Cells to Map Their Utilization of Extracellular Metabolites

This study evaluates a novel laboratory method to study how certain bone marrow cells in the body take up nutrients from their environment.

PRIMARY OBJECTIVE:

I. Evaluate differences in the amount of extracellular uptake of glucose and amino acids (AAs) between pre-malignant clonal plasma cells (cPCs) and polyclonal plasma cells (pPCs).

OUTLINE: This is an observational study. Participants are assigned to 1 of 2 groups.

GROUP I: Patients undergo blood collection and bone marrow aspiration as part of their standard care and have their medical records reviewed on study.

GROUP II: Healthy volunteers undergo blood collection and bone marrow aspiration on study.

Inclusion Criteria:

• All Participants:

  • At least age 18 years or older
  • Able to provide informed consent

• MGUS Cohort:

  • International Myeloma Working Group (IMWG) criteria for the diagnosis of non-IgM MGUS

Exclusion Criteria:

• All Participants:

  • Unable to provide consent
  • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) >1
  • Prior history of adverse events with conscious sedation
  • Ongoing use of immunosuppressive medications
  • All known pregnant and lactating women will be excluded