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The aim of this study is an explorative prospective observation of retinal ganglion cell degeneration and/or inner retina degeneration in Retinitis pigmentosa patients. The rate and patterns of progression will be correlated to the outer retina layers as well as clinical and genetic data of patients. Secondary goal is to determine potential parameters for optogenetic treatment eligibility.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| imaging | Diagnostic Test | OCT, OCTA, RNFL-OCT, fundus autofluorescence, fundus imaging, flaremeter, fundus and slit lamp examination |
| Measure | Description | Time Frame |
|---|---|---|
| Thickness of ganglion cell inner plexiforme layer (GCIPL) in OCT imaging | Measuring the thickness of the ganglion cell inner plexiforme layer (GCIPL) in macula optical coherence tomography (OCT) imaging of the retina. | 6 months intervals, overall time span 5 years |
| Thickness of RNFL thickness in OCT imaging | Measuring the thickness of the retinal nerve fiber layer (RNFL) in macular and optic nerve optical coherence tomography (OCT) imaging of the retina. | 6 months intervals, overall time span 5 years |
| PD, VD, ICA of the SRP and DRP with OCTA imaging | Perfusion density (PD), vessel density (VD), intercapillary area size (ICA) of superficial retinal plexus (SRP) and deep retinal plexus (DRP) in OCTA imaging (optical coherence tomography angiography) | 6 months intervals, overall time span 5 years |
| Thickness and morphology of inner and outer retinal layers measured with OCT, fundus photography, FAF | Thickness and morphology of inner and outer retinal layers measured with optical coherence tomography (OCT), fundus photography, fundus autofluorescence (FAF) | 6-12 months intervals, overall time span 5 years |
| Changes in functional parameters such as BCVA | Changes in functional parameters such as best corrected visual acuity | 6 months intervals, overall time span 5 years |
| Correlations of outcome 1-5 with clinical data of patients | Find correlations of imaging outcomes with the clinical data of patients, such as sex, age, age of onset of disease |
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Inclusion Criteria:
Exclusion Criteria:
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Existing Retinitis pigmentosa patients at the University clinic Göttingen. Patients with Retinitis pigmentosa within Pro Retina self-help groups.
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| Name | Affiliation | Role |
|---|---|---|
| Emilie Macé, Professor | Else Kroener Fresenius Center for Optogenetic Therapies, University Medical Center Goettingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| EKFZ Else Kroener Fresenius Center for Optogenetic Therapies, University Medical Center Goettingen | Göttingen | 37075 | Germany |
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| ID | Term |
|---|---|
| D012174 | Retinitis Pigmentosa |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D058499 | Retinal Dystrophies |
| D012162 | Retinal Degeneration |
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| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood serum samples to identify levels of inflammatory markers
| 6 months intervals, overall time span 5 years |
| Correlations of outcome 1-5 with genetic data of patients | Find correlations of imaging outcomes with the Retinitis pigmentosa mutation and inheritance pattern of patients | 6 months intervals, overall time span 5 years |
| Correlation of outcome 1-5 with inflammatory markers | Correlation of imaging outcomes and disease progression with inflammatory markers collected with serum blood samples and flaremeter as well as slit lamp and fundus examination findings | 6 months intervals, overall time span 5 years |
| Correlation of inner and outer retina parameters over time | Correlation of changes in inner retina and outer retina of collected imaging data over time. | 6 months intervals, overall time span 5 years |
| D012164 |
| Retinal Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |