Prospective Exploratory Cohort Study on Ganglion Cell Degeneration in Retinitis Pigmentosa Patients

Longitudinal Characterization of Inner Retina Health in Low Vision Retinitis Pigmentosa Patients to Optimize Retinal Ganglion Cell-based Optogenetic Vision Restoration Therapy

The aim of this study is an explorative prospective observation of retinal ganglion cell degeneration and/or inner retina degeneration in Retinitis pigmentosa patients. The rate and patterns of progression will be correlated to the outer retina layers as well as clinical and genetic data of patients. Secondary goal is to determine potential parameters for optogenetic treatment eligibility.

Inclusion Criteria:

• genetically diagnosed Retintis pigmentosa
• minimum age of 18 years (legal adult age in Germany)
• patient consent for study participation

Exclusion Criteria:

• lack of capacity to consent in participation of study (unconsciousness, mental capacity, mental illness)
• reduced cooperation during imaging or examination
• age under 18 years
• presence of additional retinal diseases
• insufficient imaging quality due to hazy media (cornea, lense)