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AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pAVM with ruptured flow-related aneurysm | |||
| pAVM without ruptured flow-related aneurysm |
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| Measure | Description | Time Frame |
|---|---|---|
| characteristics of flow-related aneurysm | size ratio(aneurysm depth (mm)/parent artery diameter (mm)) | From enrollment to the end of treatment at 8 weeks |
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| Measure | Description | Time Frame |
|---|---|---|
| demographic information of pAVM-rFA | gender | From enrollment to the end of treatment at 8 weeks |
| demographic information | age when be hospitalized |
Inclusion Criteria:
Exclusion Criteria:
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Patients with posterior circulation malformations combined with ruptured or unruptured flow-related aneurysms will be included. Morphological data such as aneurysm size, location, parent artery, feeding arteries, draining vein count, malformation size, malformation location, and the ratio of malformation/aneurysm volume will be analyzed. These factors will be examined alongside medical histories of hypertension, diabetes, and coronary artery disease to investigate the risk factors for ruptured flow-related aneurysms.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yifei Wang | Contact | +86-13852665323 | wangyifei5323@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiangsu Province Hospital | Active, not recruiting | Nanjing | Jiangsu | 225500 | China | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30107479 | Result | Hung AL, Yang W, Jiang B, Garzon-Muvdi T, Caplan JM, Colby GP, Coon AL, Tamargo RJ, Huang J. The Effect of Flow-Related Aneurysms on Hemorrhagic Risk of Intracranial Arteriovenous Malformations. Neurosurgery. 2019 Oct 1;85(4):466-475. doi: 10.1093/neuros/nyy360. | |
| 25991417 | Result | Shakur SF, Amin-Hanjani S, Mostafa H, Charbel FT, Alaraj A. Hemodynamic Characteristics of Cerebral Arteriovenous Malformation Feeder Vessels With and Without Aneurysms. Stroke. 2015 Jul;46(7):1997-9. doi: 10.1161/STROKEAHA.115.009545. Epub 2015 May 19. |
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| ID | Term |
|---|---|
| D017542 | Aneurysm, Ruptured |
| D002532 | Intracranial Aneurysm |
| D001165 | Arteriovenous Malformations |
| D013345 | Subarachnoid Hemorrhage |
| ID | Term |
|---|---|
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020765 | Intracranial Arterial Diseases |
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| From enrollment to the end of treatment at 8 weeks |
| characteristics of flow-related aneurysm | aspect ratio (aneurysm depth (mm)/aneurysm neck (mm)) | From enrollment to the end of treatment at 8 weeks |
| characteristic of avm | avm location | From enrollment to the end of treatment at 8 weeks |
| characteristic of avm | Spetzler-Martin grade of avm | From enrollment to the end of treatment at 8 weeks |
| the First Affiliated Hospital of Nanjing Medical University |
| Recruiting |
| Nanjing |
| Jiangsu |
| China |
|
| 25175442 | Result | Kouznetsov E, Weill A, Ghostine JS, Gentric JC, Raymond J, Roy D. Association between posterior fossa arteriovenous malformations and prenidal aneurysm rupture: potential impact on management. Neurosurg Focus. 2014 Sep;37(3):E4. doi: 10.3171/2014.6.FOCUS14219. |
| 21839959 | Result | Lv X, Wu Z, Jiang C, Yang X, Li Y, Sun Y, Zhang N. Angioarchitectural characteristics of brain arteriovenous malformations with and without hemorrhage. World Neurosurg. 2011 Jul-Aug;76(1-2):95-9. doi: 10.1016/j.wneu.2011.01.044. |
| D002561 |
| Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D054079 | Vascular Malformations |
| D018376 | Cardiovascular Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D020300 | Intracranial Hemorrhages |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |