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| ID | Type | Description | Link |
|---|---|---|---|
| R35GM152112-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of General Medical Sciences (NIGMS) | NIH |
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Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hot and Humid with simulated burns | Experimental | Individuals will be exposed to hot and humid conditions with a simulated burn injury. |
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| Hot and Humid without simulated burns | No Intervention | Individuals will be exposed to hot and humid conditions without a simulated burn injury. | |
| Hot and Dry with simulated burns | Experimental | Individuals will be exposed to hot and dry conditions with a simulated burn injury. |
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| Hot and Dry without simulated burns | No Intervention | Individuals will be exposed to hot and dry conditions without a simulated burn injury. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Simulated burn injury via application of absorbent and impermeable material over 60% of the body | Other | Simulated burn injury via application of absorbent and impermeable material over 60% of the body |
| Measure | Description | Time Frame |
|---|---|---|
| Core Temperature | From baseline to end of 60 minutes of recovery |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate | From baseline to the end of 60 minutes of recovery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erin M Harper, B.S. | Contact | 12143454737 | erin.harper2@utsouthwestern.edu | |
| Elizabeth A Gideon, PhD | Contact | betsygideon@texashealth.org |
| Name | Affiliation | Role |
|---|---|---|
| Craig G Crandall, PhD | University of Texas Southwestern Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas | Recruiting | Dallas | Texas | 75231 | United States |
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| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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