This study aims to compare pain severity and analgesic requirements between smokers and nonsmokers following laparoscopic cholecystectomy, evaluating the efficacy of two analgesics, tramadol and nalbuphine.

The primary objectives are to estimate pain severity in smokers versus nonsmokers and identify the effect of tramadol and nalbuphine between these groups.A comparative cross-Sectional design will be employed from Allama Iqbal Teaching Hospital, DG Khan, over four months. Participants will be stratified into subgroups receiving either tramadol or nalbuphine.

Inclusion Criteria:

• Both Male and female patients are included.
• Adults' patients with Greater than 30 years of age
• Both Smoker and non-Smokers patients are added (Patients who are chain smoker at least 10 cigarettes per day).

Exclusion Criteria:

• Patients are excluded if they have smoking history other than cigarettes smoking like Vapes, Cigar and smokeless tobacco.

The study anticipates revealing significant variations in pain perception and analgesic requirements, potentially guiding tailored perioperative protocols for smokers. By addressing gaps in pain management strategies specific to smoking status, this research could enhance postoperative recovery outcomes and inform clinical practices for optimizing analgesia in diverse patient populations.