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A Clinical Study Based on Magnetic Resonance Imaging of the Lungs to Assess the Efficacy of Thermal Vapor Ablation and Pulmonary Nodule Ablation in Chronic Obstructive Pulmonary Disease After Surgery.
The efficacy of hot steam ablation for chronic obstructive pulmonary disease was evaluated using the innovative MRI sequence PREFUL_MRI, and the efficacy of pulmonary nodule ablation was evaluated using the innovative MRI sequence GRASP_MRI.
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| Measure | Description | Time Frame |
|---|---|---|
| PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam | Using the Phase-Resolved Functional Lung(PREFUL)-MRI dedicated post-processing analysis software, we can obtain images of the patient's lung ventilation and perfusion status. | From enrollment to 6 months post-surgery |
| PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam | Percentage of perfusion defect (QDP):Calculation of QDP based on PREFUL-MRI dedicated post-processing software | From enrollment to 6 months post-surgery |
| PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam | Percentage of ventilation defect (VDP):Calculation of VDP based on PREFUL-MRI dedicated post-processing software | From enrollment to 6 months post-surgery |
| PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam | Percentage of ventilation-perfusion match (VQM):Calculation of VQM based on PREFUL-MRI dedicated post-processing software | From enrollment to 6 months post-surgery |
| Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules | Quantitative parameters of GRASP-MRI images based on the Tofts model: Volume transfer coefficient(Ktrans)(/min):the rate transfer constant of gadolinium between plasma and tissue interstitium; | From enrollment to 3 months post-surgery |
| Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules |
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Inclusion Criteria:
Exclusion Criteria:
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Patients older than 18 years of age with pulmonary nodules and COPD.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Ye, MD | Contact | 021-62821990 | sjtuyl@163.com | |
| Jiayuan Sun, MD, PhD | Contact | 021-62821990 | xkyyjysun@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai chest hospital | Recruiting | Shanghai | Shanghai Municipality | 200030 | China |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Quantitative parameters of GRASP-MRI images based on the Tofts model: Interstitial volume(Ve)(0~1):the extracellular-extravascular volume; |
| From enrollment to 3 months post-surgery |
| Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules | Quantitative parameters of GRASP-MRI images based on the Tofts model: Kep: Backflow rate constant, reflecting the time constant for returning from EES to the vascular system, Kep = Ktrans / Ve. | From enrollment to 3 months post-surgery |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |