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The aim of the study is to evaluate and compare the effectiveness of extended platelet-rich fibrin (ePRF) alone and in combination with bioactive glass nanoparticles in the treatment of grade II furcation defects clinically and radiographically.
A total of 30 grade II furcation defects will be randomly divided into three groups as follows:
Group I: 10 grade II furcation defects will be treated by extended platelet-rich fibrin (ePRF) alone.
Group II: 10 grade II furcation defects will be treated by bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF).
Group III: 10 grade II furcation defects will be treated by bioactive glass nanoparticles with collagen membrane.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I | Experimental | 10 grade II furcation defects will be treated by extended platelet-rich fibrin (ePRF) alone. |
|
| Group II | Experimental | 10 grade II furcation defects will be treated by bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF). |
|
| Group III | Active Comparator | 10 grade II furcation defects will be treated by bioactive glass nanoparticles with collagen membrane. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group I (extended platelet-rich fibrin) | Procedure | mucoperiosteal flap will be raised through sulcular incisions Debridement of granulation tissue from the osseous defect and furcation will be filled with (ePRF) at the first group |
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome will be the amount of bone fill vertically and horizontally obtained in the treatment of grade II furcation defects calculated from CBCT data in millimeters | 6 months follow up |
| Measure | Description | Time Frame |
|---|---|---|
| the secondary outcomes include improvements (decrease)of probing depth in millimetres | Using UNC-15 periodontal probe to measure the probing depth from the base of the pocket to the free gingival margin. All measurements will be rounded off to the nearest millimetre. | 3 and 6 months follow up |
| the secondary outcomes include improvements (decrease)of clinical attachment level loss in millimetres |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Merna N Elnahas, Master's degree | Mansoura Unniversity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University | Al Mansurah | 35516 | Egypt |
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| Group II (bioactive glass nanoparticles mixed with extended platelet-rich fibrin) | Procedure | bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF) |
|
| Group III (bioactive glass nanoparticles and covered by a collagen membrane) | Procedure | bioactive glass nanoparticles and covered by a collagen membrane |
|
using a UNC-15 periodontal probe to measure clinical attachment level loss from the cemento-enamel junction (CEJ) to the pocket depth. All measurements will be rounded off to the nearest millimetre |
| 3 and 6 months follow up |
| the secondary outcomes include improvements (decrease) of gingival recession measured in millimetres | Using a UNC-15 periodontal probe to measure gingival recession from cemento-enamel junction (CEJ) to the free gingival margin. All measurements will be rounded off to the nearest millimetre | 3 and 6 months follow up |
| the secondary outcomes include improvements (decrease) of gingival bleeding index | It's performed through gentle probing of the orifice of the gingival crevice using a UNC-15 periodontal probe. If bleeding occurs within 10 seconds a positive finding is recorded, and the number of positive sites is recorded and then expressed as a percentage of the number of the sites examined. | 3 and 6 months follow up |
| ID | Term |
|---|---|
| D017823 | Furcation Defects |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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