Sedation-analgesia is a major concern in the management of children in pediatric intensive care units (PICUs). International guidelines recommend the use of sedation-analgesia protocols, as their implementation has already proven effective in pediatrics. However, maintaining their long-term application remains a challenge. Indeed, healthcare teams adherence to these protocols tends to decrease over time, thereby compromising their long-term impact. This study aims to evaluate the impact of multimodal nurses training on improving and sustaining adherence to sedation-analgesia protocols. This is a non-randomized, before-and-after interventional prospective study conducted in two mixed pediatric intensive care units (Lyon and Nantes). The investigators seek to evaluate sedation practices before and after the implementation of specific multimodal training for nurses on the sedation-analgesia protocol. The primary outcome is protocol adherence. Secondary outcomes include the duration of mechanical ventilation and PICU stay, the number of daily COMFORT-B score assessments, total medication doses, the incidence of ventilator-associated pneumonia, and a qualitative analysis of non-adherence factors.

Inclusion Criteria :

• patients aged 0 to 18 years
• admitted to the PICU
• requiring mechanical ventilation
• receiving continuous sedation for more than 24 hour

Exclusion Criteria :

• patients requiring mechanical ventilation for more than 15 days
• transferred from another unit where sedation had already been initiated
• patients under sedation as part of withdrawing and withholding life-sustaining treatment
• deceased patients
• preexisting tracheostomies