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The goal of this clinical trial is to learn if the DeepPriorCBCT model ensure high-quality CBCT image while reducing CBCT radiation dose. The main questions it aims to answer are:
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants will receive a 1/6 views undersampling lung CBCT scan. | Experimental | Participants will receive a 1/6 views undersampling lung CBCT scan. And the CBCT images will be reconstructed by DeepPriorCBCT model for further analysis. |
|
| Participants will receive a full-sampling lung CBCT scan. | No Intervention | Participants will receive a full-sampling lung CBCT scan. And the CBCT images will be reconstructed by current clinical method for further analysis. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Participants will receive a 1/6 views undersampling lung CBCT scan. | Radiation | Participants will receive a 1/6 views undersampling lung CBCT scan. And the CBCT images will be reconstructed by DeepPriorCBCT model for further analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| CBCT Images Quality Score | CBCT Images Quality Score was analyzed by 5 radiologists using 5-point Likert scale. | No more than 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| The scores of lesion diagnosis from 5 radiologists | 5 radiologists from 5 medical centers will be invited to diagnosis the lesion of fully sampled machine-reconstructed CBCT images vs. undersampled model-reconstructed CBCT images. | No more than 1 week |
| The agreement scores given by the 25 interventionalists. |
| Measure | Description | Time Frame |
|---|---|---|
| Objective indicators for reconstructed CBCT images | Objective indicators for reconstructed CBCT images include peak signal to noise ratio (PSNR) and structure similarity (SSIM). PSNR is a ratio that represents the ratio between the maximum possible power of a signal and the destructive noise power that affects its representation accuracy. SSIM is a metric for measuring image similarity. | No more than 1 week. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital East Campus of Zhengzhou University | Zhengzhou | Henan | China | |||
| The First Affiliated Hospital of Zhengzhou University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37946058 | Result | Bosch de Basea M, Thierry-Chef I, Harbron R, Hauptmann M, Byrnes G, Bernier MO, Le Cornet L, Dabin J, Ferro G, Istad TS, Jahnen A, Lee C, Maccia C, Malchair F, Olerud H, Simon SL, Figuerola J, Peiro A, Engels H, Johansen C, Blettner M, Kaijser M, Kjaerheim K, Berrington de Gonzalez A, Journy N, Meulepas JM, Moissonnier M, Nordenskjold A, Pokora R, Ronckers C, Schuz J, Kesminiene A, Cardis E. Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults. Nat Med. 2023 Dec;29(12):3111-3119. doi: 10.1038/s41591-023-02620-0. Epub 2023 Nov 9. | |
| 35040882 |
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25 interventionalists from 5 medical centers will be invited to analyze fully sampled machine-reconstructed CBCT images vs. undersampled model-reconstructed CBCT images. The scores given by the 25 interventionalists will be used for agreement score analysis. |
| No more than 1 week. |
| Radiation dose | Radiation dose is defined as the radiation dose received by patients when undergoing one conventional-dose CBCT scan and one undersampled CBCT scan. | No more than 1 day |
| Zhengzhou |
| Henan |
| China |
| Wuhan Union Hospital | Wuhan | Hubei | 430022 | China |
| Wuhan Union Jinyin Lake Hospital | Wuhan | Hubei | 430022 | China |
| Wuhan Union West Hospital | Wuhan | Hubei | 430022 | China |
| Result |
| Mazzone PJ, Lam L. Evaluating the Patient With a Pulmonary Nodule: A Review. JAMA. 2022 Jan 18;327(3):264-273. doi: 10.1001/jama.2021.24287. |