YiqiJiangzhuoHuoxueTongluo Method to Delay the Occurrence of End-stage Renal Disease in Diabetic Kidney Disease--Study1

Evidence-based Evaluation of Yiqi Jiangzhuo Huoxue Tongluo Method in Delaying the Occurrence of End-stage Renal Disease in Diabetic Kidney Disease--Study 1

In order to reduce the clinical demand for kidney dialysis rate of Diabetic Kidney Disease（DKD） patients, a bidirectional cohort study of 4472 patients with DKD (Qi deficiency and collateral stasis syndrome) was carried out based on a preliminary DKD cohort of 13,000 patients. The exposure factor was supplementing and reducing the kidney turbidity-Huoxue Tongluo method represented by the addition and subversion of Shenzhuo prescription, and the incidence of end-stage renal disease was the main therapeutic index. Follow-up was conducted for 2 years

Inclusion Criteria:

• 1 in line with Western medicine diagnostic criteria for type 2 diabetic kidney disease ;
• 2 18-80 years old, regardless of gender ;
• 3 eGFR > 15ml / ( min · 1.73m2 ) ; the eGFR was calculated according to the chronic kidney disease epidemiology collaboration equation ( CKD-EPI ).
• 4 In line with the diagnostic criteria of qi deficiency and collateral stasis syndrome in traditional Chinese medicine ;
• 5glycosylated hemoglobin ( HbA1c ) between 7-10 % ;
• 6 blood pressure ≤ 160 / 100mmHg ;
• 7 to sign the informed consent ;

Exclusion Criteria:

• 1 combined with other clear renal diseases, such as polycystic kidney disease, glomerulonephritis, renal tumor, etc. ;
• 2 patients with a history of recurrent genitourinary tract infection ;
• 3 combined with cardiovascular and cerebrovascular, digestive, respiratory, urinary, immune system serious diseases or mental diseases ;
• 4 currently in pregnancy, lactation, or pregnancy plan women ;
• 5 Patients with type 1 diabetes.
• 6 Tumor patients undergoing radiotherapy, chemotherapy or targeted therapy.