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| Name | Class |
|---|---|
| University Hospital, Bordeaux | OTHER |
| University Hospital, Limoges | OTHER |
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Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
High-flow nasal oxygen (HFNO) improves comfort, reduces the risk of intubation and may reduce the risk of mortality in the most severe patients with acute hypoxemic respiratory failure compared with other oxygenation strategies. Therefore, HFNO is recommended as a first-line non-invasive oxygenation strategy in acute hypoxemic respiratory failure.
The timing of weaning patients from HFNO is complex. On the one hand, failure to wean from HFNO is associated with prolonged duration of HFNO and prolonged ICU stay. On the other hand, continued HFNO in patients ready to be weaned may unnecessarily prolong ICU stay and contribute to overwhelming of ICU capacities.
The overarching goal of this study is to identify the characteristics of patients in whom weaning from HFNO is not beneficial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFNO weaning trial group | Patients who underwent at least one weaning trial from HFNO | ||
| No HFNO weaning trial group | Patients who did not underwent HFNO weaning trial |
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| Measure | Description | Time Frame |
|---|---|---|
| Hospital-free days at day 90 | The number of days alive out of hospital between pseudorandomization and D90. For patients who died, the hospital-free days at day 90 will be equal to 0. | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of intensive care unit (ICU) stay | The number of days spent in the ICU | 90 days |
| ICU mortality | The number (and proportion) of patients who died in the ICU |
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Inclusion Criteria:
Exclusion Criteria:
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All ICU patients admitted to the 3 participating centers and treated with HFNO at the attending physician's discretion for acute respiratory failure.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bordeaux | Bordeaux | 33400 | France | |||
| University Hospital Limoges |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31511996 | Background | Rodriguez M, Thille AW, Boissier F, Veinstein A, Chatellier D, Robert R, Le Pape S, Frat JP, Coudroy R. Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study. Ann Intensive Care. 2019 Sep 11;9(1):101. doi: 10.1186/s13613-019-0578-8. | |
| 34649974 |
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Data will be made available after reasonable request and it has been discussed among the steering committee.
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| 90 days |
| Survival at day 90 | The number (and proportion) of patients alive at day 90 from pseudorandomization | 90 days |
| Limoges |
| France |
| University Hospital Poitiers | Poitiers | 86000 | France |
| Oczkowski S, Ergan B, Bos L, Chatwin M, Ferrer M, Gregoretti C, Heunks L, Frat JP, Longhini F, Nava S, Navalesi P, Ozsancak Ugurlu A, Pisani L, Renda T, Thille AW, Winck JC, Windisch W, Tonia T, Boyd J, Sotgiu G, Scala R. ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure. Eur Respir J. 2022 Apr 14;59(4):2101574. doi: 10.1183/13993003.01574-2021. Print 2022 Apr. |