A Study of LY3985863 in Healthy Participants

A Phase 1, Participant- and Investigator-Blind, Randomized, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Subcutaneous Doses of LY3985863 in Healthy Chinese Participants

The purpose of this study is to evaluate how well LY3985863 is tolerated and what side effects may occur in healthy Chinese participants. The study drug will be administered subcutaneously (SC) (under the skin).

Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body.

Inclusion Criteria:

• Are native Chinese participants
• Are overtly healthy
• Have body weight of at least 50.0 kilogram (kg) for male or 45.0 kg for female and a body mass index of 20.0 to 30.0 kilogram per square meter (kg/m²), inclusive
• Have a stable body weight within 3 months

Exclusion Criteria:

• Have known allergies to any components of the LY3985863 formulation
• Have concomitant disease known to influence skeletal muscle protein
• Have current or a history of comorbidities capable of significantly altering the absorption, metabolism, or elimination of drugs, of constituting a risk when taking the study medication or completing study procedures, or of interfering with the interpretation of the data
• Have a 12-lead echocardiogram (ECG) abnormality
• Have used within 3 months or intend to use medications during the study that promote weight loss