The purpose of this study is to learn what happens to MK-8527 in a person's body over time (a pharmacokinetic [PK] study). Researchers will compare what happens to MK-8527 in the body when it is given to healthy participants and participants with mild and moderate hepatic (liver) impairment.

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

All participants:

• Is a continuous non-smoker or moderate smoker (≤ 10 cigarettes per day or equivalent) for at least 3 months prior to dosing
• Has body mass index (BMI) ≥ 18.0 and ≤ 40.0 kg/m^2

Participants with Mild HI (Group 1) and Moderate HI (Group 2):

• Has mild or moderate hepatic impairment
• Has a diagnosis of chronic, stable, hepatic insufficiency with features of cirrhosis due to any etiology
• Is generally in good health with the exception of HI

Healthy Control Participants (Group 3):

- Healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, vital signs, and ECGs

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

All participants:

• Has a history of cancer (malignancy)
• Has positive results for human immunodeficiency virus (HIV)
• Has had major surgery and/or donated or lost significant volume of blood within 56 days prior to dosing

Participants with Mild HI (Group 1) and Moderate HI (Group 2):

• With the exception of HI, has a history or presence of clinically significant medical or psychiatric condition or disease
• Is positive for Hepatitis B surface antigen (HBsAg) or Hepatitis B core antibody (HBcAb)
• Is positive for Hepatitis C Virus (HCV)

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf