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This study aims to evaluate the effect of intralipid infusion on reversing the spinal anesthesia effect in day case surgery.
The increasing demand for day-case surgery has led to a growing interest in developing strategies to provide patients with a more convenient, cost-effective, and less invasive alternative to traditional inpatient procedures.
Spinal anesthesia, in particular, is a widely used technique in day-case surgery due to its ability to provide excellent analgesia with minimal side effects.
Intravenous lipid emulsion therapy is commonly used to treat local anesthetic systemic toxicity (LAST) and has demonstrated some efficacy in treating other drug toxicities, particularly cardiotoxicity from lipophilic drugs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group S | Experimental | Patients (>70kg will receive 100 ml, <70 will receive 1.5ml/kg) of 20% intravenous lipid emulsion at the end of surgery as a study group. |
|
| Group C | No Intervention | Patients will not receive intravenous lipid emulsion as a control group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lipid emulsion | Other | Patients (>70kg will receive 100 ml, <70 will receive 1.5ml/kg) of 20% intravenous lipid emulsion at the end of surgery as a study group. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Onset time of the motor block | The onset time of the motor block using the modified Bromage scale will be assessed. The motor block will be measured when the maximum dermatomal spread is achieved using the modified Bromage scale (0: no motor block, 1: hip blocked, 2: hip and knee blocked, and 3: hip, knee, and ankle blocked). | Intraoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of motor block | The motor block will be measured when the maximum dermatomal spread is achieved using the modified Bromage scale (0: no motor block, 1: hip blocked, 2: hip and knee blocked, and 3: hip, knee, and ankle blocked). | Intraoperatively |
| Time till home readiness |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Banha University | Banhā | Banha | 13511 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| ID | Term |
|---|---|
| D005217 | Fat Emulsions, Intravenous |
| ID | Term |
|---|---|
| D004655 | Emulsions |
| D003102 | Colloids |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
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The time to home readiness will be assessed as the time from the end of surgery until the patients reached a post-anesthesia discharge score (PADS) ≥9 and are able to void spontaneously. |
| 24 hours postoperatively |
| Time to the 1st rescue analgesia | Time to the first request for the rescue analgesia (time from end of surgery to first dose of tramadol administrated). | 24 hours postoperatively |
| Total tramadol consumption | Rescue analgesia of 100mg IV tramadol will be given if the numerical rating scale (NRS)> 3 to be repeated after 30 min if pain persists (with maximum dose 400mg) until the NRS < 4. | 24 hours postoperatively |
| Degree of pain | Each patient will be instructed about postoperative pain assessment with the numerical rating scale (NRS). NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). | 24 hours postoperatively |
| Incidence of adverse events | Incidence of adverse events such as bradycardia, urinary retention, leg paralysis, or any other complication will be recorded. | 24 hours postoperatively |
| Time from the end of surgery till movement | Time from the end of surgery till movement will be recorded. | 24 hours postoperatively |
| D057947 |
| Parenteral Nutrition Solutions |
| D019999 | Pharmaceutical Solutions |
| D012996 | Solutions |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |