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This is a prospective, non-randomized, multicenter observational registry study designed to systematically evaluate the long-term efficacy and safety of catheter ablation for treating atrial fibrillation (AF) and ventricular tachycardia (VT) in Chinese patients.
With the advancement of cardiac electrophysiology, the latest radiofrequency ablation technologies have played a significant role in the treatment of AF and VT. However, long-term outcome data on the application of these advanced techniques in Chinese patients still remains limited. The prospective, non-randomized, multicenter observational registry study will be divided into two cohorts:
These data will provide critical reference information for future diagnostic and management strategies for complex arrhythmias.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PAF | Paroxysmal atrial fibrillation |
| |
| PeAF | Persistent atrial fibrillation |
| |
| VT | Ventricular tachycardia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AF ablation | Procedure | Catheter ablation will be performed under general anesthesia or local anesthesia. Pulmonary vein isolation (PVI) was performed in all patients. Beyond this mandatory step, the specific ablation strategy/protocol and ablation parameters/settings will be determined at the discretion of the operating physicians at each participating center. |
| Measure | Description | Time Frame |
|---|---|---|
| Freedom from any documented atrial arrhythmia in 12 months after the index ablation procedure | From the end of the 3-month blanking period post-ablation to the 12-month follow-up | |
| Composite outcomes of ventricular tachycardia recurrence, cardiovascular hospitalization, or death during the 12-month follow-up | Recurrent ventricular tachycardia is defined as any appropriate implantable cardiac defibrillation therapy (shock or antitachycardia pacing) or documented sustained monomorphic ventricular tachycardia >30 seconds. Cardiovascular rehospitalization is defined as a hospital admission after the randomly assigned procedure for heart failure, procedure-associated complications, or arrhythmic causes during the 12-month follow-up. | 12 months |
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Atrial Fibrillation (AF) Cohort:
Inclusion Criteria (Patients must meet ALL of the following criteria):
Exclusion Criteria (Patients meeting ANY of the following criteria will be excluded):
Ventricular Tachycardia (VT) Cohort
Inclusion Criteria (Patients must meet ALL of the following criteria):
Exclusion Criteria (Patients meeting ANY of the following criteria will be excluded):
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A total of 4,000 patients who first undergo ablation will be included and divided into three cohorts: 1,000 in the PAF cohort, 2,000 in the PeAF cohort, and 1,000 in the organic VT cohort.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deyong Long, MD | Contact | +86 (010) 84005361 | dragon2008@vip.sina.com | |
| Deyong Long | Contact | +86 (010) 84005361 | dragon2008@vip.sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Deyong Long | Beijing Anzhen Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| No. 2 Anzhen Rd, Chaoyang District, 100029 | Recruiting | Beijing | Beijing Municipality | 100029 | China | |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D017180 | Tachycardia, Ventricular |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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|
| VT ablation | Procedure | For patients with hemodynamically stable VT, comprehensive chamber mapping (including activation mapping, substrate mapping, and entrainment mapping) is recommended. This aims to elucidate the VT activation sequence and identify the critical isthmus. Precise ablation targeting the isthmus should be performed to terminate the VT. For patients with hemodynamically unstable VT, substrate mapping during sinus rhythm can be performed first. This includes identification of low-voltage zones and abnormal electrograms (e.g., late potentials, local abnormal ventricular activities - LAVAs). Targeted substrate modification ablation should then be conducted based on the mapping findings. For all patients, complete substrate mapping is recommended after VT termination. |
|
| Beijing Anzhen Hospital, Capital Medical University |
| Not yet recruiting |
| Beijing |
| China |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D013610 | Tachycardia |
| D000075224 | Cardiac Conduction System Disease |