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| Name | Class |
|---|---|
| University of Aberdeen | OTHER |
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This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB). The aim of the current study is to explore factors affecting patient decisions to start preventive treatment. The specific objectives are to understand how patients make decisions about preventive treatment initiation for TB (stage 1); and to design and conduct a "discrete choice experiment" survey to further evaluate preferences (stage 2).
We will perform up to 30 semi-structured interviews among people undergoing testing for latent TB infection, as part of routine clinical screening programmes (stage 1). Adults (aged ≥18 years) who have been or are being tested for LTBI in routine clinical services will be eligible for inclusion through purposive sampling. The findings from the qualitative study will then be used to inform the a discrete choice experiment (DCE). The DCE will be conducted to quantify the trade-off between future TB risk and preventive treatment acceptance, from patient and healthcare provided perspectives (stage 2).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient participants for qualitative stage (stage 1) | Semi-structured interviews will first be conducted among 20-30 people undergoing testing for latent tuberculosis infection, as part of routine clinical screening programmes (Stage 1). | ||
| Patient participants for discrete choice experiment (stage 2) | 200 patients will then undertake a quantitative discrete choice experiment to evaluate preferences and trade-offs that influence acceptance of preventive TB treatment. | ||
| Healthcare worker participants for discrete choice experiment (stage 2) | 200 healthcare workers will also undertake a quantitative discrete choice experiment to evaluate preferences and trade-offs that influence recommendation of preventive TB treatment. |
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| Measure | Description | Time Frame |
|---|---|---|
| Preventive treatment acceptance | Discrete choice experiment data will be analysed to evaluate the primary outcome of preventive TB treatment acceptance in the survey. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rishi K Gupta, PhD | Contact | 020 3549 5979 | r.gupta@ucl.ac.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Whittington Hospital | Recruiting | London | United Kingdom |
Anonymised data from the discrete choice experiment will be made publicly available at the time of peer-reviewed publication.
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Indefinitely from the time of peer-reviewed publication.
The anonymised discrete choice experiment data will be publicly available
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| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D055985 | Latent Tuberculosis |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D000085343 | Latent Infection |