Acronym: VULCA-NODE Study Title: Sentinel Node Biopsy in Relapsed Vulvar Cancer Primary Objetive: To evaluate the SLN detection rate in the first recurrent vulvar carcinoma setting.

Secondary Objetives:

• To compare the utility of different tracers in the detection of SLN for recurrent disease and the injection pattern.
• To evaluate the surgical complications rate.
• To analyze the nodal status by ultrastaging .
• To assess the disease free and overall survival at 24 months from the first recurrence, as well as the dissemination pattern after the procedure.

Study Design: International prospective multicentre study

Inclusion Criteria:

• First local recurrent squamous cell carcinoma of the vulva (SCC).
• Unifocal, smaller or equal than 4 cm vulvar tumor not involving urethra, vagina or anus.
• No distant or groin metastasis.
• To be able to understand the study and sign informed consent.
• Over 18 years old.
• To be able to undergo planned follow up.

Exclusion Criteria:

• Multifocal recurrent disease of the vulva.
• Previous bilateral IFL.
• Synchronous, non-curable second malignancy. Timing: 4 years

Inclusion Criteria:

• First local recurrent squamous cell carcinoma of the vulva (SCC).
• Unifocal, smaller or equal than 4 cm vulvar tumor not involving urethra, vagina or anus.
• No distant or groin metastasis.
• To be able to understand the study and sign informed consent.
• Over 18 years old.
• To be able to undergo planned follow up.

Exclusion Criteria:

• Multifocal recurrent disease of the vulva.
• Previous bilateral IFL.
• Synchronous, non-curable second malignancy.