Study on Platelet-Rich Fibrin for Preserving Jawbone After Tooth Extraction Using CBCT Imaging in Adults

Radiographic Assessment of the Effects of Platelet-Rich Fibrin on Socket Preservation: A Case-Control Study

The goal of this clinical trial is to learn if platelet-rich fibrin (PRF), a substance made from a person's own blood, helps preserve the bone in the jaw after tooth extraction in adults. The main questions it aims to answer are:

Does PRF help reduce the loss of bone height after tooth removal? Does PRF improve how much of the socket fills with new bone?

Researchers will compare extraction sites treated with PRF to untreated sites in the same person to see if PRF helps preserve more bone.

Participants will:

Have two teeth removed on opposite sides of the mouth Receive PRF in one socket, while the other socket is left to heal naturally Undergo 3D X-ray scans (CBCT) right after extraction and again 3 months later

This study will help researchers understand if using PRF alone can improve healing and reduce bone loss after tooth extraction.

Inclusion Criteria:

Participants were eligible for inclusion if they met the following criteria:

• Age ≥ 18 years

• Smoking fewer than 10 cigarettes per day

• Presence of adequate bony support (≥ 60%)

• Indications for bilateral tooth extraction

• Patients classified as ASA I or II (American Society of Anesthesiologists).

• No systemic conditions known to impair healing, including the following:

  • Use of bisphosphonates
  • Anticoagulant or antiplatelet therapy
  • History of head and neck radiotherapy
  • Chronic use of NSAIDs or corticosteroids

Exclusion Criteria:

Patients were excluded if they met any of the following conditions:

• ASA classification III or IV
• Pregnancy or lactation
• Presence of active infection at the surgical site or need for medications beyond standard analgesics
• Presence of chronic lesions at the extraction site (patients requiring curettage of the lesion were included; those with acute infection requiring antibiotics were excluded).