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researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension
If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Noradrenaline | Active Comparator | Noradrenaline will be infused at a fixed rate of 0.2 mic/kg/min at 5 minutes before induction |
|
| Control | No Intervention | Patients will receive normal saline |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction | Drug | noradrenaline will be given at a rate of 0.2 mcg/kg/min that will start 5 minutes before induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of post induction hypotension in both groups | Hypotension will be considered if MAP< 65 mmHg | Within the first 10 minutes of induction. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of acute kidney injury | defined as the highest postoperative value > 1.5-fold or 0.3 mg/dL greater than the preoperative value | 7 days post operative |
| Incidence of myocardial infarction |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Cairo | Cairo Governorate | 6890 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8489054 | Result | Goertz AW, Lindner KH, Seefelder C, Schirmer U, Beyer M, Georgieff M. Effect of phenylephrine bolus administration on global left ventricular function in patients with coronary artery disease and patients with valvular aortic stenosis. Anesthesiology. 1993 May;78(5):834-41. doi: 10.1097/00000542-199305000-00005. | |
| 37083989 | Result |
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IPD may not be shared due to privacy concerns, regulatory restrictions, and informed consent limitations.
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D009638 | Norepinephrine |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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defined as a peak troponin T value exceeding 15 times the normal upper limit, along with new pathological Q waves, ST elevation or depression, and hyperacute T wave on ECG and symptoms suggestive of myocardial infarction
| 7 days postoperative |
| Incidence of stroke | clinical or image finding of stroke | 7 days postoperative |
| Czajka S, Putowski Z, Krzych LJ. Post-induction hypotension and intraoperative hypotension as potential separate risk factors for the adverse outcome: a cohort study. J Anesth. 2023 Jun;37(3):442-450. doi: 10.1007/s00540-023-03191-7. Epub 2023 Apr 21. |
| 38022743 | Result | Tangkulpanich P, Angkoontassaneeyarat C, Trainarongsakul T, Jenpanitpong C. Factors Associated with Postintubation Hypotension Among Patients with Suspected Sepsis in Emergency Department. Open Access Emerg Med. 2023 Nov 14;15:427-436. doi: 10.2147/OAEM.S426822. eCollection 2023. |
| 41965525 | Derived | Helmy MA, Mostafa MS, Saber AT, Ali MA, Ismail IA, Naguib BA, Elaraby MM, Milad LM. Preemptive noradrenaline infusion: a game-changer against post-induction hypotension in surgical sepsis: a randomized double blind trial. BMC Anesthesiol. 2026 Apr 11;26(1):236. doi: 10.1186/s12871-026-03783-2. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000588 |
| Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |