Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).

Brachytherapy Fractionation Individualized by Treatment Feasibility in Cervical Cancer: Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).

This is a prospective non-randomized clinical trial to evaluate the feasibility of 3 fraction versus a standard 4 fraction high dose rate brachytherapy regimen in patients with locally advanced cervical cancer.

Inclusion Criteria:

• Histologically documented malignancy of the cervix and planned to receive brachytherapy as part of definitive treatment.
• ECOG performance status of 0-2
• Age ≥ 18 years old.
• Ability to understand and the willingness to provide written informed consent.

Exclusion Criteria:

• Contraindication to receiving radiotherapy as determined by treating radiation oncologist.
• Contraindication to receiving MRI.
• Prior radiation to the pelvis > 3 months ago
• Age < 18 years old.
• Pregnant or breast-feeding