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The study is being conducted to evaluate the efficacy and safety of HRS-1893 for obstructive hypertrophic cardiomyopathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HRS-1893 Group | Experimental |
| |
| HRS-1893 Placebo Group | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HRS-1893 Tablets | Drug | HRS-1893 tablets. |
| |
| HRS-1893 Placebo Tablets |
| Measure | Description | Time Frame |
|---|---|---|
| The clinical response rate of treatment with HRS-1893. | After 24 weeks of HRS-1893 treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of major adverse cardiac events (cardiovascular death, cardiac arrest, non-fatal stroke, non-fatal myocardial infarction, hospitalization for cardiovascular events). | About 29 weeks. | |
| Incidence and severity of any adverse events. | About 29 weeks. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yun Jin | Contact | +86-0518-82342973 | yun.jin.yj1@hengrui.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College | Recruiting | Beijing | Beijing Municipality | 100032 | China |
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| ID | Term |
|---|---|
| D002312 | Cardiomyopathy, Hypertrophic |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001020 | Aortic Stenosis, Subvalvular |
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| Drug |
HRS-1893 placebo tablets. |
|
| The change in Kansas City Cardiomyopathy Questionnaire - Clinical Summary Score (KCCQ-CSS) from the baseline. | Week 12 and Week 24. |
| D001024 |
| Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |