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| ID | Type | Description | Link |
|---|---|---|---|
| GAZI-ROSC-494-2025 | Other Identifier | Gazi Yaşargil Training and Research Hospital Ethics Committee |
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This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Eligible patients admitted to the intensive care unit between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Clinical, biochemical, and resuscitation-related parameters recorded within the first 24 hours of ICU admission were analyzed. The primary objective was to determine factors independently associated with short-term mortality. Six-month mortality was additionally assessed using hospital records and the national death registry. The findings are expected to improve risk stratification and clinical decision-making in post-cardiac arrest care.
This retrospective observational cohort study was conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. Adult patients (≥18 years) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the ICU between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval.
Baseline demographic, clinical, laboratory, and resuscitation-related variables recorded within the first 24 hours of ICU admission were extracted from hospital records. These variables included arrest characteristics, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, laboratory biomarkers, and therapeutic interventions routinely performed in ICU practice.
The primary outcome was 30-day all-cause mortality. Secondary outcomes included 24-hour, 7-day, and 6-month mortality, neurological outcome at hospital discharge, and ICU length of stay. Six-month mortality status was confirmed using hospital records and the national death registry.
A total of 168 eligible patients were identified during the study period. Multivariate logistic regression analysis was performed to identify independent predictors of mortality. No interventions beyond routine clinical care were conducted.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ROSC Cohort | Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit. These patients are prospectively followed to evaluate clinical and biochemical predictors of in-hospital mortality. |
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| Measure | Description | Time Frame |
|---|---|---|
| 30-Day Mortality | All-cause mortality within 30 days of ICU admission following ROSC. | 30 days after ICU admission |
| Measure | Description | Time Frame |
|---|---|---|
| In-Hospital Mortality | All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC). | From ICU admission to hospital discharge (up to 60 days) |
| 6-Month Mortality |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit (ICU) at Gazi Yaşargil Training and Research Hospital, Turkey. Patients are consecutively enrolled and observed for outcomes related to in-hospital and 6-month mortality.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gazi Yaşargil Training and Research Hospital | Diyarbakır | Kayapinar | 21070 | Turkey (Türkiye) |
At this stage, no final decision has been made regarding individual participant data (IPD) sharing. The possibility of sharing anonymized IPD will be evaluated after the study is completed and initial results are published, taking into account ethical, legal, and institutional considerations.
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Eligible patients were identified retrospectively from institutional records and included in the analysis.
A total of 168 adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest were included in this retrospective cohort study.
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| ID | Title | Description |
|---|---|---|
| FG000 | Overall Cohort | All adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Overall Cohort | All adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | 30-Day Mortality | All-cause mortality within 30 days of ICU admission following ROSC. | All enrolled patients (n=168) were included in the analysis. | Posted | Number | participants | 30 days after ICU admission |
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Up to 180 days after ICU admission
Adverse events were not systematically collected due to the retrospective observational design of the study.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Overall Cohort | All adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest. |
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This study is limited by its retrospective single-center design. Adverse events were not systematically collected. Residual confounding cannot be excluded.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Ahmet Duzgun, MD, Intensive Care Specialist | Department of Intensive Care, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey | +90 544 674 5460 | a.duzgun47@gmail.com |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Apr 16, 2026 | Apr 16, 2026 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D006323 | Heart Arrest |
| D020925 | Hypoxia-Ischemia, Brain |
| D003128 | Coma |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |
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All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry.
| 6 months after ICU admission |
| years |
|
| Sex: Female, Male | All participants were included in the analysis; the sum of male and female participants equals the overall number. | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| APACHE II score | The Acute Physiology and Chronic Health Evaluation II (APACHE II) score is a severity-of-illness scoring scale used to predict mortality risk in critically ill adult patients. The total score ranges from 0 to 71 points, with higher scores indicating more severe disease and a higher risk of hospital mortality. The score is calculated from 12 acute physiological variables, age, and chronic health conditions, and is assessed within the first 24 hours of ICU admission (baseline) | Mean | Standard Deviation | score |
|
| SOFA score | he Sequential Organ Failure Assessment (SOFA) score is a clinical scoring scale used to assess organ dysfunction/failure in critically ill patients. The total score ranges from 0 to 24 points, with higher scores indicating more severe organ dysfunction and worse clinical outcomes. The score is calculated from six organ systems (respiratory, coagulation, liver, cardiovascular, central nervous system, and renal), each scored from 0 to 4 points, and is assessed at ICU admission (baseline). | Mean | Standard Deviation | score |
|
| SAPS 3 score | The Simplified Acute Physiology Score 3 (SAPS 3) is a severity-of-illness scoring scale used to estimate the risk of hospital mortality in critically ill patients. The total score ranges from 0 to 217 points, with higher scores indicating greater disease severity and a higher risk of mortality. The score is calculated using demographic, physiological, and clinical variables assessed at ICU admission (baseline) | Mean | Standard Deviation | score |
|
| Charlson Comorbidity Index | The Charlson Comorbidity Index (CCI) is a weighted index used to quantify comorbidity burden and predict mortality in patients with chronic diseases. Each comorbidity is assigned a score of 1, 2, 3, or 6 points depending on the associated risk of mortality. The total score ranges from 0 upwards, with higher scores indicating greater comorbidity burden and higher risk of mortality. The index is calculated based on pre-existing comorbidities documented at ICU admission (baseline). | Mean | Standard Deviation | score |
|
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| Secondary | In-Hospital Mortality | All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC). | All enrolled patients (n=168) were included in the analysis. | Posted | Number | participants | From ICU admission to hospital discharge (up to 60 days) |
|
|
|
| Secondary | 6-Month Mortality | All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry. | All enrolled patients (n=168) were included in the analysis. | Posted | Number | participants | 6 months after ICU admission |
|
|
|
| 130 |
| 168 |
| 0 |
| 168 |
| 0 |
| 168 |
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| D002318 | Cardiovascular Diseases |
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D002534 | Hypoxia, Brain |
| D014652 | Vascular Diseases |
| D000860 | Hypoxia |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |