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The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8_hydroxy_deoxyguanosine and catalase) and measuring oral health condition by plaque index.
90 male subjects will be enrolled in this study between 30_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x_ray department and 30 subjects unexposed from laboratory department in the same hospitals.
The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salivary redox biomarkers | Radiation | Salivary redox biomarkers |
| Measure | Description | Time Frame |
|---|---|---|
| oral health status | Changes in the clinical periodontal parameter (Plaque index ) To determine the patients' plaque index, their dental plaque thickness was evaluated by probing the mesial, distal, buccal, and palatal surfaces of all teeth using a Williams periodontal probe. The individual's plaque index was determined by summing the values obtained for each tooth and calculating the averages.Silness & Löe (Silness & Löe,1964) reference values were taken as a basis The Plaque Index (PI) scores each site on a 0 to 3 scale Score 0 : No plaque is in the area adjacent to the gingiva. Score 1: There is a plaque in the form of a thin film on the gingival margin. Score 2: There is a visible plaque in the gingival pocket and gingival margin. Score 3: There is a dense plaque in the gingival pocket and on the gingival margin. | Baseline: the subjects must be fasting. up to two hours saliva collection |
| Measure | Description | Time Frame |
|---|---|---|
| Salivary Malondialdehyde biomarker | Measure salivary malondialdehyde biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field | Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects. |
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Inclusion Criteria:
Exclusion Criteria:
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Male workers in radiation field from 30_40 years old who exposed to radiation for 5_10 years and compare them with male workers in laboratory at age 30_40 years
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jihan Munther Hussien, B.D.S | Contact | +9647719770649 | jihanmunther@uomustansiriyah.edu.iq |
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| Salivary 8_ hydroxy_deoxyguanosine biomarker | Measure salivary 8_hydroxy_deoxyguanosine biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field | Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects. |
| Salivary catalase biomarker | Measure salivary catalase biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field | Baseline:saliva collection for catalase . up to two hours fasting for all subjects. |