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Amino acid PET imaging could represent a biomarker for the evaluation of IDH inhibitor treatments for patients with refractory IDH-mutated gliomas
Amino acid PET imaging could represent a biomarker for the evaluation of IDH inhibitor treatments for patients with refractory IDH-mutated gliomas In fact, this study will allow us to assess, using Rano 1.0 criteria for PET and Rano 2.0 criteria for MRI, which of the two examinations is most effective in assessing the efficacy of anti-IDH treatment patients with refractory IDH-mutated gliomas.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amino-acid PET | Other | Patients received 18-fluoroDopa then a PET exam |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the performance between amino acid PET and brain MRI to assess a treatment efficacy | Comparison between early therapeutic response according to RANO 1.0 and RANO 2.0 PET criteria and tumor progression at 6 months | one day |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the performance between amino acid PET and brain MRI to assess a treatment efficacy for the identification of lesions | Determination of the number of lesions assessable by amino acid PET according to RANO 1.0 PET criteria and by MRI according to RANO 2.0 criteria | one day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent amino acid PET for early assessment of therapeutic response of IDH-mutated gliomas under anti-IDH treatment between February 2022 and November 2024
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU of NANCY | Vandœuvre-lès-Nancy | 54511 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41995839 | Result | Stien G, Obara T, Truong M, Zaragori T, Blonski M, Taillandier L, Verger A. Amino acid PET imaging to monitor mIDH inhibitor treatments in patients with refractory IDH-mutant gliomas. Eur J Nucl Med Mol Imaging. 2026 Jul;53(8):5101-5109. doi: 10.1007/s00259-026-07895-2. Epub 2026 Apr 17. |
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| ID | Term |
|---|---|
| D005910 | Glioma |
| ID | Term |
|---|---|
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |