This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.

Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments.

This study aims to investigate the treatment efficacy of TI deep brain stimulation by including essential tremor patients aged 30-70. Before and after TI stimulation, clinical data will be recorded. Clinical and imaging data will be analyzed and processed to advance the treatment of essential tremor.

Inclusion Criteria:

• Aged 30-70 years old, regardless of gender. Action tremor and postural tremor in both upper limbs, or action tremor and postural tremor in one limb;
• No history of mental diseases;
• Informed consent signed.

Exclusion Criteria:

• Presence of other neurological diseases affecting the study (such as epilepsy);
• Patients with moderate to severe cognitive impairment (Montreal Cognitive Assessment ≤ 18 points);
• Orthopedic diseases that may affect motor symptoms;
• Patients taking antipsychotic or antidepressant medications;
• Presence of metal implants in the body (such as brain pacemakers or cardiac pacemakers);
• History of electroconvulsive therapy;
• Presence of cardiovascular risk factors, etc.