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This study examines the impact of Respiratory Syncytial Virus (RSV) on people of all ages, from infants to the elderly. It uses hospital records collected between January 2018 and December 2024 to understand:
This study is designed to analyze the impact of Respiratory Syncytial Virus (RSV) across different age groups. It focuses on how often RSV occurs, who is most at risk, and its long-term and financial effects. The study uses existing hospital records from SEHA facilities between January 2018 and December 2024. This is a retrospective observational study, meaning no new tests or treatments are given. Researchers look at medical records from past patients who were diagnosed with RSV. Anonymized data is collected from SEHA's Electronic Medical Records (EMR) and laboratory systems. Only patients with confirmed RSV infections are included.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infants, adults, elderly, and high-risk patients with confirmed RSV infection (2018-2024). | This retrospective study includes patients of all ages with confirmed Respiratory Syncytial Virus (RSV) infection from January 2018 to December 2024, categorized into four cohorts: (1) Infants and young children, including those with risk factors such as prematurity, low birth weight, and chronic lung or heart disease; (2) Adults aged 18-64 years with or without comorbidities; (3) Elderly adults aged 65 and older, with focus on severe outcomes and mortality; and (4) High-risk individuals across all age groups with underlying conditions such as asthma, COPD, diabetes, immunosuppression, Down syndrome, or cystic fibrosis. No interventions are administered; the study analyzes existing data to assess RSV burden, ICU admissions, long-term health impacts, and associated healthcare costs. |
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| Measure | Description | Time Frame |
|---|---|---|
| Burden of RSV Infection Across All Age Groups | Measurement of the incidence of confirmed RSV infections in patients of all ages using SEHA hospital data from January 2018 to December 2024. | January 2018 - December 2024 |
| Burden of RSV Infection Across All Age Groups | Measurement of the prevalence of confirmed RSV infections in patients of all ages using SEHA hospital data from January 2018 to December 2024. | January 2018 - December 2024 |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of Risk Factors for Severe RSV Infection | Analysis of clinical, demographic, and comorbidity data to identify key risk factors associated with severe RSV infection outcomes. | January 2018 - December 2024 |
| Proportion of Hospital Admissions Due to RSV |
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Inclusion Criteria:
Exclusion Criteria:
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This study includes all patients of any age who have a laboratory-confirmed diagnosis of Respiratory Syncytial Virus (RSV) infection recorded in the SEHA electronic medical records between January 2018 and December 2024. The population spans from newborn infants to elderly adults, including those with underlying medical conditions such as chronic lung disease, heart disease, immunosuppression, and other comorbidities that may influence RSV severity. Both hospitalized patients and those diagnosed in outpatient settings within SEHA healthcare facilities are included. The study aims to represent the full spectrum of RSV disease burden, clinical outcomes, risk factors, long-term health impacts, and healthcare costs across diverse demographic groups in the UAE.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lina Khairy, MD | Contact | +971589111897 | o-lkhayri@seha.ae | |
| Alina Naeem, MBBS, MS | Contact | +971566089799 | alina.naeem@purehealth.ae |
| Name | Affiliation | Role |
|---|---|---|
| Salah Eldin Hussein, MD | Abu Dhabi Health Services Company-SEHA | Study Director |
| Nawal Alkaabi, MD | Abu Dhabi Health Services Company-SEHA | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheikh Khalifa Medical City (Abu Dhabi Health Research Centre), SEHA | Abu Dhabi | United Arab Emirates |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15032890 | Background | Felton DA. A time of 'firsts'. J Prosthodont. 2004 Mar;13(1):1-2. doi: 10.1111/j.1532-849X.2004.04011.x. No abstract available. | |
| 22495079 | Background | Zhou H, Thompson WW, Viboud CG, Ringholz CM, Cheng PY, Steiner C, Abedi GR, Anderson LJ, Brammer L, Shay DK. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012 May;54(10):1427-36. doi: 10.1093/cid/cis211. Epub 2012 Apr 10. |
| Label | URL |
|---|---|
| World Health Organization (WHO) - RSV Fact Sheet | View source |
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| ID | Term |
|---|---|
| D007239 | Infections |
| D001988 | Bronchiolitis |
| D011014 | Pneumonia |
| D018357 | Respiratory Syncytial Virus Infections |
| D001249 | Asthma |
| D012135 | Respiratory Sounds |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
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Evaluation of the percentage of total hospital admissions attributed to RSV infections. |
| January 2018 - December 2024 |
| ICU Admission Rates for RSV-Infected Patients | Measurement of the proportion of RSV patients requiring ICU care. | January 2018 - December 2024 |
| Financial Burden of RSV Infection | Assessment of direct medical costs associated with RSV hospitalization and ICU care. | January 2018 - December 2024 |
| Incidence of Recurrent Wheezing and Asthma Diagnosis Following RSV Infection | Evaluation of long-term respiratory complications, specifically:
| Up to 12 months post-infection |
| RSV-Associated Mortality Rates | Analysis of death rates among RSV-positive patients, including 30-day mortality post-admission. | January 2018 - December 2024 |
| Long-Term Respiratory Outcomes Following RSV Infection | Evaluation of post-RSV respiratory complications such as asthma and recurrent wheezing. | Up to 12 months post-infection |
| 19196675 | Background | Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009 Feb 5;360(6):588-98. doi: 10.1056/NEJMoa0804877. |
| 14722881 | Background | Wassmer SC, Lepolard C, Traore B, Pouvelle B, Gysin J, Grau GE. Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells. J Infect Dis. 2004 Jan 15;189(2):180-9. doi: 10.1086/380761. Epub 2004 Jan 9. |
| 11113843 | Background | Callen A, Diener-West M, Zeitlin PL, Rubenstein RC. A simplified cyclic adenosine monophosphate-mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function. J Pediatr. 2000 Dec;137(6):849-55. doi: 10.1067/mpd.2000.109198. |
| 15858184 | Background | Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005 Apr 28;352(17):1749-59. doi: 10.1056/NEJMoa043951. |
| 39575134 | Background | Joury J, Al Kaabi N, Al Dallal S, Mahboub B, Zayed M, Abdelaziz M, Onwumeh-Okwundu J, Fletcher MA, Kumaresan S, Ramachandrachar BC, Farghaly M. Retrospective Analysis of RSV Infection in Pediatric Patients: Epidemiology, Comorbidities, Treatment, and Costs in Dubai (2014-2023). J Health Econ Outcomes Res. 2024 Nov 5;11(2):133-144. doi: 10.36469/001c.123889. eCollection 2024. |
| 20399493 | Background | Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simoes EA, Rudan I, Weber MW, Campbell H. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010 May 1;375(9725):1545-55. doi: 10.1016/S0140-6736(10)60206-1. |
| Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. | View source |
| Respiratory syncytial virus infection in elderly and high-risk adults. | View source |
| Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid. | View source |
| Risk factors for severe respiratory syncytial virus infection in elderly persons. | View source |
| The burden of respiratory syncytial virus infection in young children. | View source |
| Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. | View source |
| Economic impact of respiratory syncytial virus-related illness in the US: an analysis of national databases. | View source |
| D008173 |
| Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D018186 | Pneumovirus Infections |
| D018184 | Paramyxoviridae Infections |
| D018701 | Mononegavirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |