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The goal of this clinical trial is to learn if dihydroartemisinin (DHA) works to treat Androgenetic Alopecia (AGA) in female adults. The main question it aims to answer is:
• Does DHA increase terminal hair follicles in the vertex area. Researchers will compare oral DHA plus topical minoxidil to topical minoxidil alone in female patients with AGA to see if DHA works to alleviate AGA.
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Arm | Active Comparator | oral dihydroartemisinin (DHA) combined with topical minoxidil |
|
| Control Arm | Other | topical minoxidil alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral DHA + Topical minoxidil 5% | Drug | DHA 20mg tid po plus daily topical minoxidil 5% for 180 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in terminal hair follicles in the vertex area | Terminal hair follicles in the vertex area will be quantified before and at the end of treatment | Baseline and 180-day of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change of terminal hair follicle density in the vertex area from baseline to the end of treatment | Baseline and 180-day of treatment | |
| Change of hair density in the vertex area from baseline to the end of treatment | Baseline and 180-day of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lujuan GAO, MD, PhD | Contact | 86-021-64041990 | gao.lujuan@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jingjing JIANG, MD, PhD | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Hospital Fudan University | Recruiting | Shanghai | Shanghai Municipality | 200032 | China |
All IPD that underlie results in a publication
After publication
IPD and supporting information will be avaible to researchers upon reasonable request (e.g. with a practical and meaningful research proposal)
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| ID | Term |
|---|---|
| D000505 | Alopecia |
| ID | Term |
|---|---|
| D007039 | Hypotrichosis |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Topical Minoxidil 5% | Drug | Topical minoxidil 5% daily for 180 days |
|
| Change of terminal hair follicle density in the frontal area from baseline to the end of treatment | Terminal hair follicle density in the frontal area | Baseline and 180-day of treatment |
| Change of hair density in the frontal area from baseline to the end of treatment | Baseline and 180-day of treatment |
| Change of serum total testosterone from baseline to the end of treatment | Baseline and 180-day of treatment |
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |