The objective of this observational study is to understand the long-term impact of surgery and gamma knife treatment on primary central diffuse large B-cell lymphoma. The main questions it aims to answer are:

Can surgery and gamma knife prolong the survival period of patients with primary central diffuse large B-cell lymphoma? Participants who have already incorporated surgery and gamma knife as part of the routine medical care for patients with primary central diffuse large B-cell lymphoma will answer questions about survival period within 5 years.

Inclusion Criteria:

pathologically confirmed PCNS-DLBCL complete clinical records detailing treatment methods and surgical approaches.

Exclusion Criteria:

incomplete systemic treatment data loss to follow-up after initial contact prior receipt of whole-brain radiotherapy.

A retrospective analysis was conducted on data from patients diagnosed with primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) at Nanfang Hospital between December 2006 and December 2023. A total of 76 patients were included in this study, with follow-up continuing until July 2024.