Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to learn if dihydroartemisinin (DHA) works to treat Acne Vulgaris in adults. The main question it aims to answer is:
• Does DHA improve the acne severity by at least one grade after treatment. Researchers will treat patients who are clinically diagnosed as Acne Vulgaris to see if DHA works to alleviate the symptoms of Acne Vulgaris.
Participants will:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DHA (dihydroartemisinin) Arm | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dihydroartemisinin | Drug | DHA 40mg tid for 90 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of acne severity by Investigator's Global Assessment (IGA) | Improvement of acne severity is considered clinically significant if a subject's IGA improves by at least one grade | Before and immediately after 90-day treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Global Acne Grading System (GAGS) score from baseline to the end of treatment | An improvement of ≥30% in the GAGS score will be considered significant | Before and immediately after 90-day treatment |
| Change of inflammatory lesion count from baseline to the end of treatment |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lujuan GAO, MD, PhD | Contact | 86-021-64041990 | gao.lujuan@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jingjing JIANG, MD, PhD | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Hospital Fudan University | Recruiting | Shanghai | Shanghai Municipality | 200032 | China |
All IPD that underlie results in a publication
After publication
IPD and supporting information will be avaible to researchers upon reasonable request (e.g. with a practical and meaningful research proposal).
Not provided
Not provided
| ID | Term |
|---|---|
| D000152 | Acne Vulgaris |
| ID | Term |
|---|---|
| D017486 | Acneiform Eruptions |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012625 | Sebaceous Gland Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C039060 | artenimol |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Before and immediately after 90-day treatment |
| Change of non-inflammatory lesion count from baseline to the end of treatment | Before and immediately after 90-day treatment |
| Number of participants who achieved an IGA score of 0 or 1 at the end of treatment | Before and immediately after 90-day treatment |
| Change of serum total testosterone from baseline to the end of treatment | Before and immediately after 90-day treatment |