This outcome measure includes a structured assessment of participants' understanding and personal perspective regarding menopause. The evaluation comprises the following elements: perception of menopause, definitions of menopause, history of hormone therapy (HT) use, perception and expectations regarding HT, and perceived impact of HT on menopause experience.

These variables will be aggregated to generate a descriptive profile of knowledge and self-perception of menopause for each participant.

This outcome measure includes anthropometric and physiological parameters: weight (in kilograms), height (in centimeters), body mass index (BMI, calculated as weight/height² in kg/m²), waist circumference (in centimeters), hip circumference (in centimeters), and blood pressure (in mmHg). These variables will be aggregated to generate an anthropometric profile for each participant, allowing for descriptive and comparative analysis of body composition and cardiovascular markers.

This outcome measure includes a structured assessment of the participant's self-reported health status and medical history. It comprises self-perception of health, history of surgeries, pre-existing comorbidities, and current use of medications.

These variables will be aggregated into a descriptive health profile for each participant.

This outcome measure includes laboratory test results related to metabolic, hormonal, and glycemic profiles. The following biomarkers will be collected: Thyroid-Stimulating Hormone (TSH), Free Thyroxine (T4), Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), Estradiol, Progesterone, Total Cholesterol, Low-Density Lipoprotein Cholesterol (LDL), High-Density Lipoprotein Cholesterol (HDL), Triglycerides, Fasting Glucose, and Glycated Hemoglobin. These results will be aggregated to form a laboratory profile for each participant.

This outcome measure includes a structured assessment of socioeconomic profile, access to healthcare and employment status. The variables assessed in socioeconomic classification are according to the Brazilian Association of Companies and Research (ABEP) and were used to analyze the socioeconomic level, which includes the educational level of the head of household, and includes questions about family income, possession of public items and services offered in its residence. These data will be aggregated to generate a social profile for each participant.

This outcome measure includes key demographic variables relevant to reproductive and social background: marital status, education level, race/skin color, number of children, number of pregnancies, and number of abortions. These data will be aggregated to produce a comprehensive understanding of the demographic participant profile.

This outcome measure includes a structured assessment of lifestyle-related behaviors. The variables assessed are history of smoking, physical activity practice, alcohol consumption, and use of psychoactive substances. These variables will be aggregated to produce a lifestyle profile for each participant.

Women's health questionnaire (WHQ/QSM) is used to evaluate quality of life. This validated 36-item questionnaire measures changes in nine domains of physical and emotional health associated with the menopause transition. Analysis results in a score between 0.00 and 1.00, where higher scores are associated with worse symptomology and quality of life. A change of 0.10-0.20 is clinically meaningful.

The SF-36 is a 36-item, 8-domain questionnaire used to assess overall health: physical functioning, role physical, role emotional, bodily pain, vitality, social functioning, mental health, and general health. Items are answered on Likert scales of varying lengths. Items from 8 domains contribute to the PCS. The summary scores range from 0 to 100, with higher scores indicating better levels of function and/or better health

The WPAI (Work Productivity and Activity Impairment) is questionnaire created as a patient-reported quantitative assessment. This questionnaire has 6 questions, which are used to calculate 4 types of scores; which are absenteeism (work time missed), presenteeism (reduced on the job effectiveness), work productivity loss (overall work impairment) and activity impairment. The scores are expressed in percentage with higher numbers indicating greater impairment and less productivity

The GAD-7 is a self-administered questionnaire that assesses generalized anxiety, composed of seven questions covering aspects such as excessive worry, difficulty controlling worry, irritability, muscle tension, fatigue, difficulty relaxing, and sleep problems. Each question is scored from 0 to 3, with a severity score ranging from 0 to 21. Cutoff points are ≥5 for mild anxiety, ≥10 for moderate anxiety, and ≥15 for severe anxiety.

The PHQ-9 is a self-administered questionnaire focused on depression, consisting of nine questions addressing aspects like diminished interest, depressed mood, fatigue, sleep issues, appetite changes, low self-esteem, difficulty concentrating, slowed movements or agitation, and suicidal thoughts. Each question is scored from 0 to 3, with a severity score from 0 to 27. Severe depression is indicated by a score >16.