Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this observational retrospective study is to assess whether serum lipid levels differ between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy individuals. The study aims to evaluate if alterations in lipid parameters, especially LDL levels, are associated with the presence of lip SCC and could serve as potential early biomarkers.
The main research questions are:
Do patients with lip SCC show significantly lower LDL levels compared to healthy controls? Are there significant differences in total cholesterol (TC), triglycerides (TG), HDL, and VLDL between the two groups? A retrospective analysis was conducted using existing medical records of patients with lip SCC and healthy subjects obtained from 2018-2023.
Demographic data and lipid profile information were collected from 56 patients (28 lip SCC and 28 healthy). The lipid parameters included were total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | patients clinically evident and histopathologically confirmed with lip SCC | ||
| control group | subjects without any underlying systemic disease |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Low-Density Lipoprotein (LDL) Levels in Patients With Lip SCC vs. Healthy Controls | To assess whether there is a statistically significant difference in fasting serum LDL levels between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy subjects. | At time of diagnosis (retrospective data collection) |
| Measure | Description | Time Frame |
|---|---|---|
| Total Cholesterol (TC) Levels in Patients With Lip SCC vs. Healthy Controls | To compare fasting serum total cholesterol (TC) levels between lip SCC patients and healthy controls. | At time of diagnosis (retrospective data collection) |
| Triglycerides (TG) Levels in Patients With Lip SCC vs. Healthy Controls |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Data from patients with a histopathological diagnosis of primary lip cancers at Antalya Training and Research Hospital, Turkiye.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Eldar Rasljanin, DDS | Akdeniz University, Antalya, Turkiye | Principal Investigator |
| Özer Erdem Gür, MD | Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye | Principal Investigator |
| Rezarta Taga Senirli, MD | Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye | Principal Investigator |
| Busehan Bilgin, DDS | Akdeniz University, Antalya, Turkiye | Principal Investigator |
| Öznur Özalp, DDS | Akdeniz University, Antalya, Turkiye | Principal Investigator |
| Mehmet Ali Altay, DDS, PhD | Akdeniz University, Antalya, Turkiye | Principal Investigator |
| Alper Sindel, DDS, PhD | Akdeniz University, Antalya, Turkiye | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akdeniz University | Antalya | 07070 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20002982 | Background | Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010 Feb;39(2):141-8. doi: 10.1111/j.1600-0714.2009.00828.x. Epub 2009 Dec 7. | |
| 6799076 | Background | Kark JD, Smith AH, Hames CG. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):152-4. doi: 10.1136/bmj.284.6310.152. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002294 | Carcinoma, Squamous Cell |
| D008048 | Lip Neoplasms |
| D009062 | Mouth Neoplasms |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
Not provided
Not provided
Not provided
Not provided
Not provided
To evaluate fasting serum TG levels in lip SCC patients compared to controls. |
| At time of diagnosis (retrospective data collection) |
| High-Density Lipoprotein (HDL) Levels in Patients With Lip SCC vs. Healthy Controls | To compare HDL levels between lip SCC patients and healthy controls. | At time of diagnosis (retrospective data collection) |
| Very Low-Density Lipoprotein (VLDL) Levels in Patients With Lip SCC vs. Healthy Controls | To compare fasting serum VLDL levels between study and control groups. | At time of diagnosis (retrospective data collection) |
| 25097644 | Background | Mehta R, Gurudath S, Dayansoor S, Pai A, Ganapathy KS. Serum lipid profile in patients with oral cancer and oral precancerous conditions. Dent Res J (Isfahan). 2014 May;11(3):345-50. doi: 10.4103/1735-3327.135889. |
| 23174719 | Background | Kumar P, Augustine J, Urs AB, Arora S, Gupta S, Mohanty VR. Serum lipid profile in oral cancer and leukoplakia: correlation with tobacco abuse and histological grading. J Cancer Res Ther. 2012 Jul-Sep;8(3):384-8. doi: 10.4103/0973-1482.103517. |
| 2804926 | Background | Gerber M, Richardson S, Crastes de Paulet P, Pujol H, Crastes de Paulet A. Relationship between vitamin E and polyunsaturated fatty acids in breast cancer. Nutritional and metabolic aspects. Cancer. 1989 Dec 1;64(11):2347-53. doi: 10.1002/1097-0142(19891201)64:113.0.co;2-v. |
| 9840100 | Background | Forones NM, Falcao JB, Mattos D, Barone B. Cholesterolemia in colorectal cancer. Hepatogastroenterology. 1998 Sep-Oct;45(23):1531-4. |
| 12139232 | Background | Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002 Jul-Aug;52(4):195-215. doi: 10.3322/canjclin.52.4.195. |
| 15105576 | Background | Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, Patel JB, Patel DD. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer. 2004 Jan-Mar;41(1):25-31. |
| 3677028 | Background | Alexopoulos CG, Blatsios B, Avgerinos A. Serum lipids and lipoprotein disorders in cancer patients. Cancer. 1987 Dec 15;60(12):3065-70. doi: 10.1002/1097-0142(19871215)60:123.0.co;2-q. |
| 26899131 | Background | Acharya S, Rai P, Hallikeri K, Anehosur V, Kale J. Serum lipid profile in oral squamous cell carcinoma: alterations and association with some clinicopathological parameters and tobacco use. Int J Oral Maxillofac Surg. 2016 Jun;45(6):713-20. doi: 10.1016/j.ijom.2016.01.015. Epub 2016 Feb 19. |
| 28157733 | Background | Bota JP, Lyons AB, Carroll BT. Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction. Dermatol Surg. 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. |
| 29898090 | Background | Moro JDS, Maroneze MC, Ardenghi TM, Barin LM, Danesi CC. Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (Sao Paulo). 2018 Jun 7;16(2):eAO4248. doi: 10.1590/S1679-45082018AO4248. |
| 27832256 | Background | Han AY, Kuan EC, Mallen-St Clair J, Alonso JE, Arshi A, St John MA. Epidemiology of Squamous Cell Carcinoma of the Lip in the United States: A Population-Based Cohort Analysis. JAMA Otolaryngol Head Neck Surg. 2016 Dec 1;142(12):1216-1223. doi: 10.1001/jamaoto.2016.3455. |
| 35368013 | Background | Louredo BV, Vargas PA, Perez-de-Oliveira ME, Lopes MA, Kowalski LP, Curado MP. Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population. Med Oral Patol Oral Cir Bucal. 2022 May 1;27(3):e274-e284. doi: 10.4317/medoral.25147. |
| 35732291 | Background | Tranby EP, Heaton LJ, Tomar SL, Kelly AL, Fager GL, Backley M, Frantsve-Hawley J. Oral Cancer Prevalence, Mortality, and Costs in Medicaid and Commercial Insurance Claims Data. Cancer Epidemiol Biomarkers Prev. 2022 Sep 2;31(9):1849-1857. doi: 10.1158/1055-9965.EPI-22-0114. |
| D018307 |
| Neoplasms, Squamous Cell |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D008047 | Lip Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |