This is a single arm, open label, national multicenter clinical study included patients with chronic lymphocytic leukemia (CLL). The treatment combines three medications: Zanubrutinib , Obinutuzumab and Bendamustine . Together, these drugs aim to achieve deep remission (no detectable cancer cells) and allow a shorter treatment duration compared to lifelong therapies.

Inclusion Criteria:

1. Demographics: Age ≥18 years, regardless of gender.

2. Diagnosis: Confirmed diagnosis of untreated chronic lymphocytic leukemia (CLL) per iwCLL 2018 criteria.

3. Treatment Naivety:

   • No prior systemic therapy for CLL, including:
   • CHOP/COP-based chemotherapy.
   • Regimens containing fludarabine or bendamustine.
   • Anti-CD20 monoclonal antibodies (e.g., rituximab) or BTK inhibitors (e.g., ibrutinib).
   • Chlorambucil or cyclophosphamide (>3 weeks of use).
   • Interferon therapy (>6 months of use).

4. Treatment Indications:

   • Must meet ≥1 of the following (iwCLL 2018 criteria):
   • Hemoglobin <100 g/L (non-hemolytic).
   • Platelets <100×10⁹/L with progressive decline.
   • Lymphadenopathy (longest diameter >10 cm) or massive splenomegaly (>6 cm below costal margin).
   • Constitutional symptoms: unexplained fever (>38°C ×2 weeks), night sweats, or >10% weight loss in 6 months.
   • Rapid disease progression (lymphocyte doubling time <6 months, 50% lymph node growth in 2 months, or rapid cytopenia).

5. Performance Status: ECOG performance status ≤2.

6. Organ Function (within 7 days before enrollment):

   Hematologic:

   • ANC ≥1.0×10⁹/L (without growth factor support).
   • Platelets ≥50×10⁹/L (without transfusion).
   • Hepatic: AST/ALT ≤2.5×ULN; total bilirubin ≤1.5×ULN.
   • Renal: Estimated CrCl ≥30 mL/min (Cockcroft-Gault formula).

7. Consent: Signed informed consent.

Exclusion Criteria:

1. Malignancy: History of active malignancy (excluding CLL) within the past year, including CNS lymphoma.
2. Disease Transformation: Richter transformation or prolymphocytic leukemia (PLL).
3. Autoimmune Cytopenias: Active autoimmune hemolysis or thrombocytopenia requiring corticosteroids.
4. Organ Dysfunction: ALT/AST >3×ULN; total bilirubin >2×ULN; creatinine >1.5×ULN.
5. Comorbidities: Uncontrolled diabetes, cardiac/pulmonary disease, or conditions deemed by investigators to affect study safety.
6. Infections: Active systemic infection requiring IV antibiotics.
7. Bleeding Risks: History of life-threatening hemorrhage or need for high-dose anticoagulation.
8. Recent Surgery: Major surgery within 30 days.
9. Reproductive Status: Pregnancy, lactation, or unwillingness to use contraception.
10. Drug Tolerance: Hypersensitivity to any study drug components.
11. Viral Infections: Active HBV (HBsAg+ or HBV-DNA+) or HCV.
12. Other: Investigator-determined ineligibility (e.g., poor compliance, psychiatric disorders).